Identified human breastmilk compositions effectively inhibit SARS-CoV-2 and variants infection and replication
iScience
; 2022.
Artículo
en Inglés
| EuropePMC | ID: covidwho-1755857
ABSTRACT
The global pandemic of COVID-19 caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection confers great threat to the public health. Human breastmilk is a complex with nutritional composition to nourish infants and protect them from different kinds of infectious diseases including COVID-19. Here, we identified lactoferrin (LF), mucin1 (MUC1) and α-lactalbumin (α-LA) from human breastmilk inhibit SARS-CoV-2 infection using a SARS-CoV-2 pseudovirus system and transcription and replication-competent SARS-CoV-2 virus-like-particles (trVLP). Additionally, LF and MUC1 inhibited multiple steps including viral attachment, entry and post-entry replication, while α-LA inhibited viral attachment and entry. Importantly, LF, MUC1 and α-LA possessed potent antiviral activities towards variants such as B.1.1.7 (alpha), B.1.351 (beta), P.1 (gamma) and B.1.617.1 (kappa). Taken together, our study provides evidence that human breastmilk components (LF, MUC1 and α-LA) are promising antiviral and potential therapeutic candidates warranting further development or treating COVID-19. Graphical
Buscar en Google
Colección:
Bases de datos de organismos internacionales
Base de datos:
EuropePMC
Tipo de estudio:
Estudio experimental
Tópicos:
Variantes
Idioma:
Inglés
Revista:
IScience
Año:
2022
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS