Sociodemographic disparities in COVID-19 seroprevalence across England in the Oxford RCGP primary care sentinel network.
J Infect
; 84(6): 814-824, 2022 06.
Artículo
en Inglés
| MEDLINE | ID: covidwho-1778314
ABSTRACT
OBJECTIVES:
To monitor changes in seroprevalence of SARS-CoV-2 antibodies in populations over time and between different demographic groups.METHODS:
A subset of practices in the Oxford-Royal College of General Practitioners (RCGP) Research and Surveillance Centre (RSC) sentinel network provided serum samples, collected when volunteer patients had routine blood tests. We tested these samples for SARS-CoV-2 antibodies using Abbott (Chicago, USA), Roche (Basel, Switzerland) and/or Euroimmun (Luebeck, Germany) assays, and linked the results to the patients' primary care computerised medical records. We report seropositivity by region and age group, and additionally examined the effects of gender, ethnicity, deprivation, rurality, shielding recommendation and smoking status.RESULTS:
We estimated seropositivity from patients aged 18-100 years old, which ranged from 4.1% (95% CI 3.1-5.3%) to 8.9% (95% CI 7.8-10.2%) across the different assays and time periods. We found higher Euroimmun seropositivity in younger age groups, people of Black and Asian ethnicity (compared to white), major conurbations, and non-smokers. We did not observe any significant effect by region, gender, deprivation, or shielding recommendation.CONCLUSIONS:
Our results suggest that prior to the vaccination programme, most of the population remained unexposed to SARS-CoV-2.Palabras clave
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
Médicos Generales
/
COVID-19
Tipo de estudio:
Estudio experimental
/
Estudio observacional
/
Ensayo controlado aleatorizado
Tópicos:
Vacunas
Límite:
Adolescente
/
Adulto
/
Anciano
/
Humanos
/
Middle aged
/
Young_adult
País/Región como asunto:
Europa
Idioma:
Inglés
Revista:
J Infect
Año:
2022
Tipo del documento:
Artículo
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