Autophagy Modulators in Coronavirus Diseases: A Double Strike in Viral Burden and Inflammation.
Front Cell Infect Microbiol
; 12: 845368, 2022.
Artículo
en Inglés
| MEDLINE | ID: covidwho-1793038
ABSTRACT
Coronaviruses are the etiologic agents of several diseases. Coronaviruses of critical medical importance are characterized by highly inflammatory pathophysiology, involving severe pulmonary impairment and infection of multiple cell types within the body. Here, we discuss the interplay between coronaviruses and autophagy regarding virus life cycle, cell resistance, and inflammation, highlighting distinct mechanisms by which autophagy restrains inflammatory responses, especially those involved in coronavirus pathogenesis. We also address different autophagy modulators available and the rationale for drug repurposing as an attractive adjunctive therapy. We focused on pharmaceuticals being tested in clinical trials with distinct mechanisms but with autophagy as a common target. These autophagy modulators act in cell resistance to virus infection and immunomodulation, providing a double-strike to prevent or treat severe disease development and death from coronaviruses diseases.
Palabras clave
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
Infecciones por Coronavirus
/
Coronavirus
Tipo de estudio:
Estudio de etiologia
/
Estudio pronóstico
Límite:
Humanos
Idioma:
Inglés
Revista:
Front Cell Infect Microbiol
Año:
2022
Tipo del documento:
Artículo
País de afiliación:
Fcimb.2022.845368
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