Crohn's Disease of the Elderly: Unique Biology and Therapeutic Efficacy and Safety.
Gastroenterol Clin North Am
; 51(2): 425-440, 2022 06.
Artículo
en Inglés
| MEDLINE | ID: covidwho-1804127
ABSTRACT
The incidence and prevalence of inflammatory bowel disease (IBD) is increasing in the elderly population. Compared with patients with onset during younger years, patients with elderly-onset IBD have a distinct clinical presentation, disease phenotype, and natural history. Genetics contribute less to pathogenesis of disease, whereas aging-related biological changes, such as immunosenescence and dysbiosis, are associated with elderly-onset IBD. Frailty is an increasingly recognized predictor of adverse outcomes. As an increasingly wider array of biologic and small molecule therapeutic options becomes available, data regarding efficacy and safety of these agents in patients are paramount given the unique characteristics of this population.
Palabras clave
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
Enfermedades Inflamatorias del Intestino
/
Colitis Ulcerosa
/
Enfermedad de Crohn
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
Límite:
Anciano
/
Humanos
Idioma:
Inglés
Revista:
Gastroenterol Clin North Am
Asunto de la revista:
Gastroenterologia
Año:
2022
Tipo del documento:
Artículo
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