Clinical characteristics and treatments of multi-system inflammatory syndrome in children: a systematic review.
Eur Rev Med Pharmacol Sci
; 26(9): 3342-3350, 2022 05.
Artículo
en Inglés
| MEDLINE | ID: covidwho-1856620
ABSTRACT
OBJECTIVE:
Multisystem inflammatory syndrome in children (MIS-C) can occur in association with coronavirus disease 2019 (COVID-19). It is not easy to differentiate MIS-C from severe COVID-19 or Kawasaki disease based on symptoms. The aim of this study was to describe the clinical and laboratory characteristics of MIS-C. PATIENTS ANDMETHODS:
We searched PubMed/Medline for case series and reports of MIS-C published until June 20, 2020. From a total of nine articles involving 45 cases, various clinical and laboratory data were extracted. Each target case was evaluated by using different diagnostic criteria.RESULTS:
The average age at onset of MIS-C was 8.6 years. In 80% of cases, the age of patients ranged from 5 to 15 years. Fever (100%) and shock (82%) were the most common presenting symptoms. Sixty percent of cases met the diagnostic criteria for typical or atypical Kawasaki disease. Biomarkers indicative of inflammation, coagulopathy, or cardiac injury were characteristically elevated as follows ferritin (mean 1,061 ng/mL), CRP (217 mg/L), ESR (69 mm/hr), IL-6 (214.8 pg/mL), TNFα (63.4 pg/mL), D-dimer (3,220 ng/mL), PT (15.5 s), troponin I (1,006 ng/L), and BNP (12,150 pg/mL). Intravenous immunoglobulin was administered in all target cases, and inotropic agents were commonly used as well. No case of death was observed.CONCLUSIONS:
This study demonstrated that MIS-C is a serious condition that presents with fever, rash, as well as cardiovascular and gastrointestinal symptoms. Although it is challenging to differentiate MIS-C from Kawasaki disease or severe COVID-19, initiation of appropriate treatments through early diagnosis is warranted.
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
COVID-19
/
Síndrome Mucocutáneo Linfonodular
Tipo de estudio:
Estudios diagnósticos
/
Estudio experimental
/
Estudio pronóstico
/
Revisiones
/
Revisión sistemática/Meta análisis
Tópicos:
Covid persistente
Límite:
Adolescente
/
Niño
/
Child, preschool
/
Humanos
Idioma:
Inglés
Revista:
Eur Rev Med Pharmacol Sci
Asunto de la revista:
Farmacología
/
Toxicología
Año:
2022
Tipo del documento:
Artículo
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