Autopsy Histopathologic Cardiac Findings in 2 Adolescents Following the Second COVID-19 Vaccine Dose.
Arch Pathol Lab Med
; 146(8): 925-929, 2022 08 01.
Artículo
en Inglés
| MEDLINE | ID: covidwho-1975265
ABSTRACT
CONTEXT. Myocarditis in adolescents has been diagnosed clinically following the administration of the second dose of an mRNA vaccine for coronavirus disease 2019 (COVID-19). OBJECTIVE. To examine the autopsy microscopic cardiac findings in adolescent deaths that occurred shortly following administration of the second Pfizer-BioNTech COVID-19 dose to determine if the myocarditis described in these instances has the typical histopathology of myocarditis. DESIGN. Clinical and autopsy investigation of 2 teenage boys who died shortly following administration of the second Pfizer-BioNTech COVID-19 dose. RESULTS. The microscopic examination revealed features resembling a catecholamine-induced injury, not typical myocarditis pathology. CONCLUSIONS. The myocardial injury seen in these postvaccine hearts is different from typical myocarditis and has an appearance most closely resembling a catecholamine-mediated stress (toxic) cardiomyopathy. Understanding that these instances are different from typical myocarditis and that cytokine storm has a known feedback loop with catecholamines may help guide screening and therapy.
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
Vacunas contra la COVID-19
/
COVID-19
/
Miocarditis
/
Miocardio
Tipo de estudio:
Reporte de caso
/
Estudio pronóstico
Tópicos:
Vacunas
Límite:
Adolescente
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Arch Pathol Lab Med
Año:
2022
Tipo del documento:
Artículo
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