Update on vitamin C administration in critical illness.
Curr Opin Crit Care
; 28(4): 374-380, 2022 08 01.
Artículo
en Inglés
| MEDLINE | ID: covidwho-1985170
ABSTRACT
PURPOSE OF REVIEW Several studies have recently explored the effects of intravenous vitamin C in sepsis. We aimed to summarize their findings to provide perspectives for future research. RECENT FINDINGS:
Sepsis trials examined 6âg/day of intravenous vitamin C with or without the thiamine and/or hydrocortisone compared with placebo or hydrocortisone. Network meta-analysis reported that intravenous vitamin C, thiamine, hydrocortisone, or combinations of these drugs was not proven to reduce long-term mortality. However, the component network meta-analysis suggested an association of high-dose (>6âg/day) and very-high dose vitamin C (>12âg/day) and decreased mortality but with low certainty. The preclinical investigations have, however, advanced to much higher doses of intravenous vitamin C therapy since a scoping review on harm reported that mega-doses of intravenous vitamin C (50-100âg/day) had been administered without any conclusive adverse effects. In a Gram-negative sheep model, renal tissue hypoperfusion was reversed, followed by improvements in kidney function when a mega-dose of vitamin C (150âg/day equivalent) was administered.SUMMARY:
The effect of intravenous vitamin C in critically ill patients has yet to be determined and might be dose-dependent. Clinical studies of very high or mega doses of vitamin C are justified by preclinical data.
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
Ácido Ascórbico
/
Sepsis
Tipo de estudio:
Estudio pronóstico
/
Ensayo controlado aleatorizado
/
Revisiones
Límite:
Animales
/
Humanos
Idioma:
Inglés
Revista:
Curr Opin Crit Care
Asunto de la revista:
Terapia intensiva
Año:
2022
Tipo del documento:
Artículo
País de afiliación:
MCC.0000000000000951
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