Risk Factors and Mechanisms of Cardiovascular Diseases in Posttraumatic Stress Disorder Model in Wistar Rats as Dependent on Stress Resistance and Age.
Dokl Biol Sci
; 505(1): 95-99, 2022 Aug.
Artículo
en Inglés
| MEDLINE | ID: covidwho-2008770
ABSTRACT
The article focuses on the pathogenetic mechanisms of posttraumatic stress disorder (PTSD), which is associated with psychological stress because of the coronavirus pandemic. The molecular mechanisms responsible for disease susceptibility in some individuals and stress resistance in others are amongst crucial research interests of experimental and clinical medicine. Priority data were obtained to indicate that distortions of synthesis and metabolism and, most significantly, a switch between two energy transport forms, glucose and lipids, underlie myocardial dysfunction in young and old stress-sensitive Wistar rats in a PTSD model. Histochemistry and polarization microscopy showed energy deficit in cardiomyocytes and signs of ischemic and hypoxic areas emerging in the myocardium as a result of an accumulation of NADH and NADPH, which initiate excessive production of reactive oxygen species.
Palabras clave
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
Trastornos por Estrés Postraumático
/
Enfermedades Cardiovasculares
Tipo de estudio:
Estudio pronóstico
Tópicos:
Covid persistente
Límite:
Animales
Idioma:
Inglés
Revista:
Dokl Biol Sci
Año:
2022
Tipo del documento:
Artículo
País de afiliación:
S0012496622040020
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