Drug utilization study in patients affected with COVID-19 in a dedicated COVID hospital
National Journal of Physiology, Pharmacy and Pharmacology
; 13(1):58-62, 2023.
Artículo
en Inglés
| CAB Abstracts | ID: covidwho-20232637
ABSTRACT
Background:
There exists a treatment dilemma regarding the optimal and effective use of therapeutic drugs (hydroxychloroquine/chloroquine/azithromycin) for COVID-19. Furthermore, with changing guidelines, the data on drug utilization patterns across India are limited. Hence, this study was conducted to assess the prescription pattern and drug utilization trends in COVID-19 patients with the aim to study the drug utilization pattern in patients affected with COVID-19 in a dedicated COVID-19 hospital. Aims andObjectives:
The objectives of the study are as follows (1) To study drug utilization patterns according to the severity of the disease. (2) To study the prevalence of adverse drug reactions (ADRs). Materials andMethods:
Data were collected retrospectively from 100 medical records of patients 18 years irrespective of sex admitted in the COVID ward and ICU of a dedicated COVID hospital from May to August 2020. Pregnant and lactating women were excluded from the study. ADRs reported were also analyzed.Results:
About 71% were mild in this study, 18% were moderate, and 11% were severe COVID-19 patients. Overall, the most common drugs prescribed were multivitamins, followed by pantoprazole, paracetamol, and azithromycin. Hydroxychloroquine was prescribed in 22%, favipiravir in 7%, and remdesivir in 3% of cases. The majority of moderate COVID patients received injectables piperacillin-tazobactam, methylprednisolone, and enoxaparin. The mean number of medications, duration of admission, and number of days on oxygen were higher and significant in moderate compared to mild and severe COVID patients. Overall, ADRs were encountered in 9% of cases.Conclusion:
The prescribed pattern of drugs was by the national standard guidelines. Multivitamins, followed by pantoprazole, paracetamol, and azithromycin dominated the prescription pattern. Polypharmacy was encountered, which needs to be addressed for the rational use of drugs.
Prion; Viral; Bacterial and Fungal Pathogens of Humans [VV210]; Pharmacology [VV730]; Pesticides and Drugs; Control [HH405]; Health Services [UU350]; coronavirus disease 2019; drug therapy; human diseases; viral diseases; medical treatment; antiviral agents; hydroxychloroquine; chloroquine; azithromycin; prescriptions; adverse effects; disease incidence; disease prevalence; epidemiology; vitamin supplements; proton pump inhibitors; acetaminophen; favipiravir; remdesivir; piperacillin; tazobactam; methylprednisolone; hospital admission; disease course; macrolide antibiotics; antibiotics; penicillins; beta-lactam antibiotics; man; Severe acute respiratory syndrome coronavirus 2; India; Maharashtra; Commonwealth of Nations; lower-middle income countries; medium Human Development Index countries; South Asia; Asia; Homo; Hominidae; primates; mammals; vertebrates; Chordata; animals; eukaryotes; Severe acute respiratory syndrome-related coronavirus; Betacoronavirus; Coronavirinae; Coronaviridae; Nidovirales; positive-sense ssRNA Viruses; ssRNA Viruses; RNA Viruses; viruses; pantoprazole; enoxaparin; chemotherapy; SARS-CoV-2; viral infections; antivirals; adverse reactions; paracetamol; disease progression
Texto completo:
Disponible
Colección:
Bases de datos de organismos internacionales
Base de datos:
CAB Abstracts
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
Idioma:
Inglés
Revista:
National Journal of Physiology, Pharmacy and Pharmacology
Año:
2023
Tipo del documento:
Artículo
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