Individualizing methadone treatment with split dosing: An underutilized tool.
J Subst Use Addict Treat
; 152: 209096, 2023 Jun 08.
Artículo
en Inglés
| MEDLINE | ID: covidwho-20233485
ABSTRACT
Methadone's long half-life typically allows for once daily dosing. However, a growing body of evidence and clinical experience shows that some patients may benefit from twice-daily ("split") dosing to produce more stable symptoms and minimize side effects, independent of serum peak-to-trough levels. Concerns regarding split dosing typically center on diversion and poor adherence and must be taken seriously. However, policy changes during COVID-19 demonstrate that the rigidity historically applied to methadone may be unnecessarily stringent. Given clinical advances and policy updates, we believe clinicians should weigh the risks and benefits of this underutilized tool for select patients, as we await the evidence-based recommendations our patients deserve.
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Tipo de estudio:
Estudio pronóstico
Tópicos:
Covid persistente
Idioma:
Inglés
Revista:
J Subst Use Addict Treat
Año:
2023
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS