Functions of double-negative B cells in autoimmune diseases, infections, and cancers.
EMBO Mol Med
; : e17341, 2023 Jun 05.
Artículo
en Inglés
| MEDLINE | ID: covidwho-20234229
ABSTRACT
Most mature B cells can be divided into four subtypes based on the expression of the surface markers IgD and CD27 IgD+ CD27- naïve B cells, IgD+ CD27+ unswitched memory B cells, IgD- CD27+ switched memory B cells, and IgD- CD27- double-negative (DN) B cells. Despite their small population size in normal peripheral blood, DN B cells play integral roles in various diseases. For example, they generate autoimmunity in autoimmune conditions, while these cells may generate both autoimmune and antipathogenic responses in COVID-19, or act in a purely antipathogenic capacity in malaria. Recently, DN B cells have been identified in nasopharyngeal carcinoma and non-small-cell lung cancers, where they may play an immunosuppressive role. The distinct functions that DN B cells play in different diseases suggest that they are a heterogeneous B-cell population. Therefore, further study of the mechanisms underlying the involvement of DN B cells in these diseases is essential for understanding their pathogenesis and the development of therapeutic strategies. Further research is thus warranted to characterize the DN B-cell population in detail.
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Idioma:
Inglés
Revista:
EMBO Mol Med
Asunto de la revista:
Biologia Molecular
Año:
2023
Tipo del documento:
Artículo
País de afiliación:
Emmm.202217341
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