A Web-Based Method for the Identification of IL6-Based Immunotoxicity in Vaccine Candidates.
Methods Mol Biol
; 2673: 317-327, 2023.
Artículo
en Inglés
| MEDLINE | ID: covidwho-20234868
ABSTRACT
Interleukin 6 (IL6) is a major pro-inflammatory cytokine that plays a pivotal role in both innate and adaptive immune responses. In the past, a number of studies reported that high level of IL6 promotes the proliferation of cancer, autoimmune disorders, and cytokine storm in COVID-19 patients. Thus, it is extremely important to identify and remove the antigenic regions from a therapeutic protein or vaccine candidate that may induce IL6-associated immunotoxicity. In order to overcome this challenge, our group has developed a computational tool, IL6pred, for discovering IL6-inducing peptides in a vaccine candidate. The aim of this chapter is to describe the potential applications and methodology of IL6pred. It sheds light on the prediction, designing, and scanning modules of IL6pred webserver and standalone package ( https//webs.iiitd.edu.in/raghava/il6pred/ ).
Palabras clave
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
Vacunas
/
COVID-19
Tipo de estudio:
Estudio pronóstico
Tópicos:
Vacunas
Límite:
Humanos
Idioma:
Inglés
Revista:
Methods Mol Biol
Asunto de la revista:
Biologia Molecular
Año:
2023
Tipo del documento:
Artículo
País de afiliación:
978-1-0716-3239-0_22
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