Modelling the impact of COVID-19 and routine MenACWY vaccination on meningococcal carriage and disease in the UK.
Epidemiol Infect
; 151: e98, 2023 06 01.
Artículo
en Inglés
| MEDLINE | ID: covidwho-20236436
ABSTRACT
Country-wide social distancing and suspension of non-emergency medical care due to the COVID-19 pandemic will undoubtedly have affected public health in multiple ways. While non-pharmaceutical interventions are expected to reduce the transmission of several infectious diseases, severe disruptions to healthcare systems have hampered diagnosis, treatment, and routine vaccination. We examined the effect of this disruption on meningococcal disease and vaccination in the UK. By adapting an existing mathematical model for meningococcal carriage, we addressed the following questions What is the predicted impact of the existing MenACWY adolescent vaccination programme? What effect might social distancing and reduced vaccine uptake both have on future epidemiology? Will catch-up vaccination campaigns be necessary? Our model indicated that the MenACWY vaccine programme was generating substantial indirect protection and suppressing transmission by 2020. COVID-19 social distancing is expected to have accelerated this decline, causing significant long-lasting reductions in both carriage prevalence of meningococcal A/C/W/Y strains and incidence of invasive meningococcal disease. In all scenarios modelled, pandemic social mixing effects outweighed potential reductions in vaccine uptake, causing an overall decline in carriage prevalence from 2020 for at least 5 years. Model outputs show strong consistency with recently published case data for England.
Palabras clave
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
Vacunas Meningococicas
/
COVID-19
/
Infecciones Meningocócicas
/
Neisseria meningitidis
Tipo de estudio:
Estudio experimental
/
Estudio observacional
/
Estudio pronóstico
Tópicos:
Vacunas
Límite:
Adolescente
/
Humanos
País/Región como asunto:
Europa
Idioma:
Inglés
Revista:
Epidemiol Infect
Asunto de la revista:
Enfermedades Transmisibles
/
Epidemiología
Año:
2023
Tipo del documento:
Artículo
País de afiliación:
S0950268823000870
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