Platelet-neutrophil interaction in COVID-19 and vaccine-induced thrombotic thrombocytopenia.
Front Immunol
; 14: 1186000, 2023.
Artículo
en Inglés
| MEDLINE | ID: covidwho-20236819
ABSTRACT
Coronavirus disease 2019 (COVID-19) is known to commonly induce a thrombotic diathesis, particularly in severely affected individuals. So far, this COVID-19-associated coagulopathy (CAC) has been partially explained by hyperactivated platelets as well as by the prothrombotic effects of neutrophil extracellular traps (NETs) released from neutrophils. However, precise insight into the bidirectional relationship between platelets and neutrophils in the pathophysiology of CAC still lags behind. Vaccine-induced thrombotic thrombocytopenia (VITT) is a rare autoimmune disorder caused by auto-antibody formation in response to immunization with adenoviral vector vaccines. VITT is associated with life-threatening thromboembolic events and thus, high fatality rates. Our concept of the thrombophilia observed in VITT is relatively new, hence a better understanding could help in the management of such patients with the potential to also prevent VITT. In this review we aim to summarize the current knowledge on platelet-neutrophil interplay in COVID-19 and VITT.
Palabras clave
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
Trombocitopenia
/
Trombosis
/
Vacunas
/
COVID-19
Tipo de estudio:
Estudio de etiologia
Tópicos:
Covid persistente
/
Vacunas
Límite:
Humanos
Idioma:
Inglés
Revista:
Front Immunol
Año:
2023
Tipo del documento:
Artículo
País de afiliación:
Fimmu.2023.1186000
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