The Association of COVID-19 Severity with Laboratory Parameters, Radiologic Findings, Maternal and Neonatal Outcomes in Pregnant Women: A Multicenter Study in Indonesia
Journal of SAFOG
; 15(2):199-205, 2023.
Artículo
en Inglés
| EMBASE | ID: covidwho-20237185
ABSTRACT
Objectives:
Severe acute respiratory syndrome-coronavirus 2/COVID-19 infection is still a global concern, with pregnant women are considered as vulnerable population. Until now, the characteristics of pregnant women in Indonesia who are infected with COVID-19, as well as pregnancy and neonatal outcomes, are still unknown. This study aims to obtain national data, which are expected to be useful for the prevention and management of COVID-19 in pregnant women in Indonesia. Method(s) There were 1,427 patients recruited in this retrospective multicenter study. This study involved 11 hospitals in 10 provinces in Indonesia and was carried out using secondary patient data from April 2020 to July 2021. COVID-19 severity was differentiated into asymptomatic-to-mild symptoms and moderate-to-severe symptoms. The collected data include maternal characteristics, laboratory examinations, imaging, pregnancy outcomes, and neonatal outcomes. Result(s) Leukocyte, platelets, basophil, neutrophils segment, lymphocytes, monocytes, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, alanine aminotransferase (ALT), aspartate aminotransferase (AST), C-reactive protein (CRP), urea, and creatinine were found to be significantly associated with severity differences (p < 0.05). Moderate-severe symptoms of COVID-19 also shown to have suggestive pneumonia findings on chest X-ray findings. Patients with asymptomatic-to-mild symptoms had significantly (p < 0.001) higher recovery rate, shorter hospital stay, less intensive care unit (ICU) admission, and had more vaginal delivery. Neonates from mother with mild symptoms also had significantly (p < 0.001) higher survival rate, higher birth weight, and higher APGAR score. Conclusion(s) Several laboratory and radiology components, as well as maternal and neonatal outcomes are related to the severity of COVID-19 in pregnant women in Indonesia.Copyright © The Author(s). 2023.
covid-19; Laboratory and radiology findings; Maternal and neonatal outcomes; Pregnancy; abortion; adult; ageusia; anorexia; anosmia; Apgar score; article; basophil count; birth weight; cesarean section; cohort analysis; coronavirus disease 2019; coughing; depression; diarrhea; disease severity; dyspnea; eosinophil count; fatigue; female; fever; gestational age; headache; hospital admission; hospitalization; human; hypoxia; Indonesia; intensive care unit; laboratory test; length of stay; leukocyte count; liver and kidney function test; lymphocyte count; maternal age; monocyte count; morbidity; mortality; multicenter study (topic); myalgia; nausea and vomiting; neutrophil count; neutrophil lymphocyte ratio; newborn; newborn death; nose obstruction; oxygen saturation; parity; platelet count; platelet lymphocyte ratio; pneumonia; polymerase chain reaction; pregnancy outcome; pregnant woman; premature labor; retrospective study; risk factor; sore throat; survival rate; thorax radiography; vaginal delivery; virus pneumonia; alanine aminotransferase/ec [Endogenous Compound]; aspartate aminotransferase/ec [Endogenous Compound]; C reactive protein/ec [Endogenous Compound]; creatinine/ec [Endogenous Compound]; hemoglobin/ec [Endogenous Compound]; procalcitonin/ec [Endogenous Compound]; urea/ec [Endogenous Compound]
Texto completo:
Disponible
Colección:
Bases de datos de organismos internacionales
Base de datos:
EMBASE
Tipo de estudio:
Estudio experimental
/
Estudio observacional
/
Estudio pronóstico
Idioma:
Inglés
Revista:
Journal of SAFOG
Año:
2023
Tipo del documento:
Artículo
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