Potential inhibition of Melaleuca leucadendron L. compounds against the NSP5 SARS CoV-2 protein
Indonesian Journal of Cancer Chemoprevention
; 13(3):195-206, 2022.
Artículo
en Inglés
| CAB Abstracts | ID: covidwho-20239622
ABSTRACT
COVID-19 is an infectious disease caused by Severe Acute Respiratory Syndrome (SARS-CoV-2), causing a global health emergency as a pandemic disease. The lack of certain drug molecules or treatment strategies to fight this disease makes it worse. Therefore, effective drug molecules are needed to fight COVID-19. Non Structural Protein (NSP5) or called Main Protease (Mpro) of SARS CoV 2, a key component of this viral replication, is considered a key target for anti-COVID-19 drug development. The purpose of this study is to determine whether the compounds in the Melaleuca leucadendron L. plant such as 1,8-cineole, terpene, guaiol, linalol, a-selinenol, beta-eudesmol and P-eudesmol are predicted to have antiviral activity for COVID-19. Interaction of compounds with NSP5 with PDB code 6WNP analyzed using molecular docking with Molegro Virtual Docker. Based on binding affinity, the highest potential as an anti-viral is Terpineol with binding energy (-119.743 kcal/mol). The results of the interaction showed that terpinol has similarities in all three amino acid residues namely Cys 145, Gly 143, and Glu 166 with remdesivir and native ligand. Melaleuca leucadendron L. may represent a potential herbal treatment to act as COVID-19 NSP5, however these findings must be validated in vitro and in vivo.
Non-food/Non-feed Plant Products [SS200]; Pesticides and Drugs; Control [HH405]; Prion; Viral; Bacterial and Fungal Pathogens of Humans [VV210]; Animal and in vitro Models for Pharmaceuticals [VV450]; Non-wood Forest Products [KK540]; antiviral properties; plant extracts; viral diseases; coronavirus disease 2019; human diseases; medicinal plants; terpenoids; amino acids; remdesivir; ligands; herbal drugs; in vitro; non-wood forest products; Severe acute respiratory syndrome coronavirus 2; Melaleuca leucadendra; man; plants; Severe acute respiratory syndrome-related coronavirus; Betacoronavirus; Coronavirinae; Coronaviridae; Nidovirales; positive-sense ssRNA Viruses; ssRNA Viruses; RNA Viruses; viruses; Melaleuca; Myrtaceae; Myrtales; eudicots; angiosperms; Spermatophyta; eukaryotes; Homo; Hominidae; primates; mammals; vertebrates; Chordata; animals; Melaleuca leucadendron; SARS-CoV-2; anti-viral properties; viral infections; drug plants; medicinal herbs; officinal plants; terpenes; herbal medicines; minor forest products; non-timber forest products
Texto completo:
Disponible
Colección:
Bases de datos de organismos internacionales
Base de datos:
CAB Abstracts
Tipo de estudio:
Estudio pronóstico
Tópicos:
Medicina tradicional
Idioma:
Inglés
Revista:
Indonesian Journal of Cancer Chemoprevention
Año:
2022
Tipo del documento:
Artículo
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