Postnatal SARSCOV2 Infection in Neonates, Characteristics and Outcomes: An Observational Study
Archives of Clinical Infectious Diseases
; 18(1) (no pagination), 2023.
Artículo
en Inglés
| EMBASE | ID: covidwho-20239807
ABSTRACT
Background:
Many aspects of the severe acute respiratory syndrome coronavirus 2 (SARSCoV2) pandemic in 2019 have been unclear, especially in newborns, and reports of neonatal diseases are usually associated with perinatal infection. Objective(s) The purpose of this study was to evaluate clinical and para-clinical manifestations in newborns that contracted the infection after birth. Method(s) This observational research was conducted from October 2020 to March 2022 to examine postnatal SARSCoV2 infection in infants admitted to the NICU or neonatal ward at the Children's Medical Center in Tehran, Iran. Inclusion in the study was open to neonates who had positive RT-PCR results postnatally. Result(s) In total, 55 newborns were confirmed to have postnatal SARSCOV2. Fever was the most frequently observed symptom, with 35 (61%). Necrotizing enterocolitis was seen in 18% of neonates, and 30% of them were preterm. Neutropenia was seen in 34% of cases, with five cases having severe neutropenia. All neonates had a normal platelet count. Twenty percent of patients showed C-reactive protein higher than 6 mg/L. Two newborns had co-existing bacterial urinary tract infections. Our neonates didn't require antiviral, anticoagulant, or corticosteroid medications, and they recovered while receiving only supportive care. Everyone in the group of newborns was discharged without complications, and there were no deaths. Conclusion(s) The high rate of fever, high C-reactive protein, and neutropenia in SARSCoV2 neonates suggests that more observational research is needed to compare these symptoms to bacterial sepsis to avoid the overuse of antibiotics in these patients.Copyright © 2023, Author(s).
Antiviral Agents; Neonate; Neutropenia; Pandemics; SARSCoV2; article; coronavirus disease 2019; coughing; cyanosis; enterocolitis; fever; human; hypothermia; lymphocyte count; milk intolerance; mother to child transmission; neonatal intensive care unit; newborn; noninvasive ventilation; observational study; polymerase chain reaction; respiratory distress; sepsis; Severe acute respiratory syndrome coronavirus 2; urinary tract infection; vomiting; anticoagulant agent; antivirus agent; C reactive protein; corticosteroid; PCR assay kit
Texto completo:
Disponible
Colección:
Bases de datos de organismos internacionales
Base de datos:
EMBASE
Tipo de estudio:
Estudio experimental
/
Estudio observacional
/
Estudio pronóstico
Idioma:
Inglés
Revista:
Archives of Clinical Infectious Diseases
Año:
2023
Tipo del documento:
Artículo
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