Optimization and Characterization of Quercetin Vitamin C Nano-Phytosome Formulation
International Journal of Applied Pharmaceutics
; 15(Special Issue 1):51-55, 2023.
Artículo
en Inglés
| EMBASE | ID: covidwho-20240315
ABSTRACT
Objective:
To design an optimal formulation for quercetin and vitamin C nano-phytosome. Method(s) Nano-phytosomes are prepared by the thin layer hydration technique using a 2-level-5-factor design experimental. A total of 32 experimental formulas were used for data analysis. The ratio of quercetin soy lecithin (X1), the ratio of quercetin cholesterol (X2), stirring speed (X3), stirring temperature (X4), and stirring time (X5) were used as independent factors, while globule size as a dependent factor. Data analysis was carried out by Design Expert12 application. Characterization of the optimal formula included physicochemical evaluation, globule size analysis, zeta potential, polydispersity index, entrapment efficiency, Transition Electron Microscopy (TEM) analysis, and FTIR analysis. Result(s) The optimal formula consisted of quercetin vitamin C lecithin cholesterol ratio of 1 1 1.046 0.105 mol;stirring speed 763.986 rpm;stirring time of 59 min, at temperature 51.73 degreeC which produced 59.26 nm average globule size, PDI value 0.66;zeta potential value-35.93+/-0.95 mV and average SPAN value 0.61. This formulation showed entrapment efficiency of quercetin 91.69+/-0.18 % and vitamin C 90.82+/-0.13 %. The TEM and FITR analysis showed the morphological of the globules and interactions between the drugs, soy lecithin, and cholesterol to form nano-phytosomes. Conclusion(s) The conditions to obtain the optimal formula for quercetin vitamin C nano-phytosome consisted of quercetin vitamin C lecithin cholesterol ratio of 1 1 1.046 0.105 mol;stirring speed 763.986 rpm;stirring time of 59 min, and at temperature 51.73 degreeC.Copyright © 2023 The Authors.
Factorial design; Nano-phytosome; Optimization; Quercetin; Vitamin C; article; coronavirus disease 2019; dispersity; encapsulation; Fourier transform infrared spectroscopy; hydration; morphology; organoleptic property; physical appearance; physical chemistry; process optimization; temperature; transmission electron microscopy; zeta potential; ascorbic acid/cb [Drug Combination]; cholesterol; dichloromethane; methanol; nanoparticle/cb [Drug Combination]; phosphatidylcholine; phytosome/cb [Drug Combination]; quercetin/cb [Drug Combination]; particle size analyzer; sonicator; spectrometer; spectrophotometer; entrapment efficiency; Elmasonic S-10 H; Perkin Elmer Spectrum 1000; Rotavapor R-100
Texto completo:
Disponible
Colección:
Bases de datos de organismos internacionales
Base de datos:
EMBASE
Tipo de estudio:
Estudio experimental
Idioma:
Inglés
Revista:
International Journal of Applied Pharmaceutics
Año:
2023
Tipo del documento:
Artículo
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