Disease X Testing: The results of an international external quality assessment exercise
Journal of Biosafety and Biosecurity
; 4(2):151-157, 2022.
Artículo
en Inglés
| EMBASE | ID: covidwho-20241592
ABSTRACT
The United Nations Secretary-General Mechanism (UNSGM) for investigation of the alleged use of chemical and biological weapons is the only established international mechanism of this type under the UN. The UNGSM may launch an international investigation, relying on a roster of expert consultants, qualified experts, and analytical laboratories nominated by the member states. Under the framework of the UNSGM, we organized an external quality assurance exercise for nominated laboratories, named the Disease X Test, to improve the ability to discover and identify new pathogens that may cause possible epidemics and to determine their animal origin. The "what-if" scenario was to identify the etiological agent responsible for an outbreak that has tested negative for many known pathogens, including viruses and bacteria. Three microbes were added to the samples, Dabie bandavirus, Mammarenavirus, and Gemella spp., of which the last two have not been taxonomically named or published. The animal samples were from Rattus norvegicus, Marmota himalayana, New Zealand white rabbit, and the tick Haemaphysalis longicornis. Of the 11 international laboratories that participated in this activity, six accurately identified pathogen X as a new Mammarenavirus, and five correctly identified the animal origin as R. norvegicus. These results showed that many laboratories under the UNSGM have the capacity and ability to identify a new virus during a possible international investigation of a suspected biological event. The technical details are discussed in this report.Copyright © 2022
Disease X testing; eqae; adolescent; adult; aged; animal tissue; article; blood sampling; Brucella melitensis; child; clinical article; controlled study; coughing; Dabie bandavirus; feces analysis; fever; Gemella; Haemaphysalis longicornis; Haemophilus parainfluenzae; headache; Herpesviridae; human; Human coronavirus 229E; JC virus; laboratory; laboratory test; Mammarenavirus; Marmota; measurement accuracy; nasopharyngeal swab; Neisseria; New Zealand White (rabbit); nonhuman; Orf virus; Oryctolagus cuniculus; Pegivirus; Prevotella melaninogenica; Pseudomonas; Puumala virus; quality control; Rattus norvegicus; virus identification; virus inactivation; Human pegivirus C; Marmota himalayana; Pseudomonas moraviensis
Texto completo:
Disponible
Colección:
Bases de datos de organismos internacionales
Base de datos:
EMBASE
Tipo de estudio:
Estudio de etiologia
Idioma:
Inglés
Revista:
Journal of Biosafety and Biosecurity
Año:
2022
Tipo del documento:
Artículo
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