Molecular Diagnostics on Smartphone
Progress in Biomedical Optics and Imaging - Proceedings of SPIE
; 12374, 2023.
Artículo
en Inglés
| Scopus | ID: covidwho-20242665
ABSTRACT
During the COVID-19 pandemic, point-of-care genetic testing (POCT) devices were used for on-time and on-site detection of the virus, which helped to prevent and control the spread of the pandemic. Smartphones, which are widely used electronic devices with many functions, have the potential to be used as a molecular diagnostic platform for universal healthcare monitoring. Several integrated diagnostics platforms for the real-time and end-point detection of COVID-19 were developed using the functions of smartphones, such as the operating system, power, sound, camera, data storage, and display. These platforms use the 5V output power of smartphones, which can be amplified to power a micro-capillary electrophoresis system or a thin-film heater, and the CMOS camera of smartphones can capture the color change during a colorimetric loop-mediated isothermal amplification test and detect fluorescence signals. Smartphones can also be used with self-written web-based apps to enable automatic and remote pathogen analysis on POCT platforms. Our lab developed a handheld micro-capillary electrophoresis device for end-point detection of SARS-CoV-2, as well as an integrated smartphone-based genetic analyzer for the qualitative and quantitative colorimetric detection of foodborne pathogens with the help of a custom mobile app. © 2023 SPIE.
capillary electrophoresis; COVID-19; loop-mediated isothermal amplification; molecular diagnostic; point-of-care genetic testing; smartphone; web-based application; Cameras; Color; Colorimetry; Digital storage; Fluorescence; Isotherms; mHealth; Smartphones; Viruses; Web services; Websites; End point detection; Genetic testing; Loop mediated isothermal amplifications; Loop-mediated isothermal amplifications; Molecular diagnostics; Point of care; Power; Smart phones; Web-based applications
Texto completo:
Disponible
Colección:
Bases de datos de organismos internacionales
Base de datos:
Scopus
Tipo de estudio:
Estudios diagnósticos
/
Investigación cualitativa
Idioma:
Inglés
Revista:
Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Año:
2023
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS