Update on nonpolio enterovirus and parechovirus infections in neonates and young infants.
Curr Opin Pediatr
; 35(3): 380-389, 2023 06 01.
Artículo
en Inglés
| MEDLINE | ID: covidwho-20243856
ABSTRACT
PURPOSE OF REVIEW To review the epidemiology, clinical manifestations, and treatment strategies of nonpolio enterovirus and parechovirus (PeV) infections, and identify research gaps. RECENT FINDINGS:
There is currently no approved antiviral agent for enterovirus or PeV infections, although pocapavir may be provided on a compassionate basis. Elucidation of the structure and functional features of enterovirus and PeV may lead to novel therapeutic strategies, including vaccine development.SUMMARY:
Nonpolio human enterovirus and PeV are common childhood infections that are most severe among neonates and young infants. Although most infections are asymptomatic, severe disease resulting in substantial morbidity and mortality occurs worldwide and has been associated with local outbreaks. Long-term sequelae are not well understood but have been reported following neonatal infection of the central nervous system. The lack of antiviral treatment and effective vaccines highlight important knowledge gaps. Active surveillance ultimately may inform preventive strategies.
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
Enterovirus
/
Infecciones por Picornaviridae
/
Parechovirus
/
Infecciones por Enterovirus
Tipo de estudio:
Estudios diagnósticos
/
Estudio observacional
/
Estudio pronóstico
Tópicos:
Covid persistente
/
Vacunas
Límite:
Niño
/
Humanos
/
Lactante
/
Recién Nacido
Idioma:
Inglés
Revista:
Curr Opin Pediatr
Asunto de la revista:
Pediatría
Año:
2023
Tipo del documento:
Artículo
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