Expressions of miR-21 TGF-beta/Smad signaling pathway in peripheral blood of bronchial asthma patients complicated with respiratory virus infection
Chinese Journal of Nosocomiology
; 33(4):522-526, 2023.
Artículo
en Chino
| GIM | ID: covidwho-20244455
ABSTRACT
OBJECTIVE:
To investigate the expressions of peripheral blood microRNA-21(miR-21) and transforming growth factor-beta(TNF-beta)/Smad signaling transduction pathway in patients with bronchial asthma complicated with respiratory virus infection.METHODS:
Totally 109 patients with asthma complicated with respiratory virus infection(study group) and 104 patients without virus infection(control group) in the Third People's Hospital of Gansu Province between Feb.2019 and Feb.2021 were selected for the cross-sectional study. The basic data of the two groups were collected, and parameters including vital signs, lung function, peripheral blood miR-21 and TGF-beta/Smad signaling pathway proteins were measured. According to the guidelines, the patients of the two groups were divided into acute exacerbation phase and stable phase. The examination results of each group were compared and the levels of peripheral blood miR-21 and TGF-beta/Smad signaling pathway proteins expression of patients with asthma complicated with respiratory virus infection were analyzed.RESULTS:
In study group, the proportion of respiratory virus infection among 109 patients was 33.94% for influenza virus, 23.85% for human rhinovirus, 19.27% for respiratory syncytial virus, 10.09% for parainfluenza virus, 6.42% for adenovirus, 4.59% for human coronavirus and 1.83% for human metapneumovirus respectively. The proportion of patients with acute exacerbation phase in the study group was higher than that in the control group, and the levels of peripheral blood miR-21, TGF-beta1, Smad7, pSmad2 and pSmad3 were higher than those in control group(P<0.05). The levels of miR-21, TGF-beta1, Smad2, Smad3, Smad7, pSmad2 and pSmad3 in peripheral blood of patients with acute exacerbation phase of asthma were higher than those of patients with stable phase of asthma(P<0.05). There were no statistical differences in peripheral blood miR-21, TGF-beta1, Smad2, Smad3, Smad7, pSmad2 and pSmad3 levels in asthma patients with different virus infections.CONCLUSION:
Early respiratory virus infections might lead to increased expression of peripheral blood miR-21 and increased activation of TGF-beta/Smad signaling pathway in patients with asthma, which played an important role in acute attack of asthma.
76057-06-2; asthma; bronchial asthma; cross-sectional studies; human coronaviruses; human diseases; human rhinoviruses; influenza viruses; lung function; lungs; parainfluenza; parainfluenza viruses; peripheral blood mononuclear cells; respiratory diseases; signal transduction; transforming growth factor; viral diseases; Adenoviridae; Comoranthus; Human metapneumovirus; Human respiratory syncytial virus; man; viruses; Coronavirinae; Enterovirus; Orthomyxoviridae; Paramyxovirinae; China; Gansu; dsDNA Viruses; DNA Viruses; APEC countries; East Asia; Asia; high Human Development Index countries; upper-middle income countries; Oleaceae; Lamiales; eudicots; angiosperms; Spermatophyta; plants; eukaryotes; North Western China; Metapneumovirus; Pneumovirinae; Paramyxoviridae; Mononegavirales; negative-sense ssRNA Viruses; ssRNA Viruses; RNA Viruses; Pneumovirus; Homo; Hominidae; primates; mammals; vertebrates; Chordata; animals; Coronaviridae; Nidovirales; positive-sense ssRNA Viruses; Picornaviridae; Picornavirales; People's Republic of China; Kansu; lung diseases; viral infections
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Colección:
Bases de datos de organismos internacionales
Base de datos:
GIM
Tipo de estudio:
Estudio experimental
/
Estudio observacional
/
Ensayo controlado aleatorizado
Idioma:
Chino
Revista:
Chinese Journal of Nosocomiology
Año:
2023
Tipo del documento:
Artículo
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