The factors associated with increased risk of hospitalisation in people with diabetes following SARS-CoV- 2 infection: A national replication study
Diabetic Medicine
; 40(Supplement 1):95, 2023.
Artículo
en Inglés
| EMBASE | ID: covidwho-20244695
ABSTRACT
Aim:
People with type 1 or type 2 diabetes have a higher hospital admission rate following Covid-19 infection. This study aims to determine the degree to which the results of a previous study in Greater Manchester (GM) could be replicated in national-level data for England. Method(s) We focussed on the univariable regression analysis, which shows the association between admission and Covid-19 infection in people with diabetes. Modelling was conducted using logistic regression on data from the Covid-IMPACT database. Odds ratios were compared descriptively with the previous study. Result(s) In people with type 2 diabetes, factors associated with an increased risk of hospitalisation similar to the previous study were older age, male sex, higher social deprivation, higher body mass index (BMI), higher cholesterol, lower eGFR, taking an ACE-inhibitor/ ARB, not taking metformin, and having asthma or hypertension. Patients with COPD, and those taking aspirin or clopidogrel also had increased risk, but the national data showed a greater risk (GM COPD odds ratio 1.89 [1.63-2.19] vs national 2.34 [2.28-2.40] / aspirin 1.49 [1.34-1.66] vs 1.66 [1.63-1.70] / clopidogrel 1.71 [1.47-1.98] vs 1.99 [1.94-2.04]). Similar results were observed in patients with type 1 diabetes. However, due to the increase in sample size, many factors which were previously not statistically significant have become significant, such as in type 2 diabetes BMI, low HDL-cholesterol. Conclusion(s) We have successfully replicated the methods, results and conclusions of our previous study in relation to factors associated with increased risk of hospital admission in diabetes individuals. Regional databases are suitable for large cohort studies, and in this instance produced similar results to a national database, validating our previous findings.
aged; asthma; body mass; chronic obstructive lung disease; cohort analysis; conference abstract; controlled study; coronavirus disease 2019; diabetes mellitus; diabetic patient; England; estimated glomerular filtration rate; female; hospital admission; hospitalization; human; hypertension; insulin dependent diabetes mellitus; male; non insulin dependent diabetes mellitus; replication study; sample size; social isolation; acetylsalicylic acid; cholesterol; clopidogrel; dipeptidyl carboxypeptidase inhibitor; high density lipoprotein cholesterol; metformin
Texto completo:
Disponible
Colección:
Bases de datos de organismos internacionales
Base de datos:
EMBASE
Tipo de estudio:
Estudio de cohorte
/
Estudio observacional
/
Estudio pronóstico
Idioma:
Inglés
Revista:
Diabetic Medicine
Año:
2023
Tipo del documento:
Artículo
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