A systematical association analysis of 25 common virus infection and genetic susceptibility of COVID-19 infection.
Microbes Infect
; : 105170, 2023 Jun 12.
Artículo
en Inglés
| MEDLINE | ID: covidwho-20245274
ABSTRACT
OBJECTIVES:
Previous studies identified a number of diseases were associated with 2019 coronavirus disease (COVID-19). However, the associations between these diseases related viral infections and COVID-19 remains unknown now.METHODS:
In this study, we utilized single nucleotide polymorphisms (SNPs) related to COVID-19 from genome-wide association study (GWAS) and individual-level genotype data from the UK biobank to calculate polygenic risk scores (PRS) of 487,409 subjects for eight COVID-19 clinical phenotypes. Then, multiple logistic regression models were established to assess the correlation between serological measurements (positive/negative) of 25 viruses and the PRS of eight COVID-19 clinical phenotypes. And we performed stratified analyses by age and gender.RESULTS:
In whole population, we identified 12 viruses associated with the PRS of COVID-19 clinical phenotypes, such as VZV seropositivity for Varicella Zoster Virus (Unscreened/Exposed_Negative ß = 0.1361, P = 0.0142; Hospitalized/Unscreened ß = 0.1167, P = 0.0385) and MCV seropositivity for Merkel Cell Polyomavirus (Unscreened/Exposed_Negative ß = -0.0614, P = 0.0478). After age stratification, we identified seven viruses associated with the PRS of eight COVID-19 clinical phenotypes. After gender stratification, we identified five viruses associated with the PRS of eight COVID-19 clinical phenotypes in the women group.CONCLUSION:
Our study findings suggest that the genetic susceptibility to different COVID-19 clinical phenotypes is associated with the infection status of various common viruses.
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Tipo de estudio:
Estudio pronóstico
Idioma:
Inglés
Revista:
Microbes Infect
Asunto de la revista:
Alergia e Inmunología
/
Microbiologia
Año:
2023
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS