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Immune System Development Processes with Special Emphasis on Relationship to Potential Mechanisms of MIS-C
Birth Defects Research ; 115(8):849.0, 2023.
Artículo en Inglés | EMBASE | ID: covidwho-20245555
ABSTRACT
Development of the mammalian immune system requires the intersection of myriad internal and external signals, from the migration of pluripotent stem cells to interactions with the vaginal microbiome during partuition to environmental factors that shape immune processes throughout life. Because the sequence of immune developmental events is fairly transcripted across time, multiple windows of susceptibility exist that can lead to immune dysfunction when these developmental events are perturbed. Additionally, early-life immune dysfunction can persist, leading to increased disease risk across the lifespan. Immune dysfunction can present functionally as suppression, hyperresponsivity, or inappropriate inflammation and molecularly, may involve multiple cells and signaling pathways. Thus, scenarios that lead to multisystem inflammatory syndrome in children (MIS-C) can be complex and multifaceted. This presentation will consider windows of susceptibility as well as external factors that may increase the risk of MIS-C.
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Texto completo: Disponible Colección: Bases de datos de organismos internacionales Base de datos: EMBASE Tipo de estudio: Estudio pronóstico Idioma: Inglés Revista: Birth Defects Research Año: 2023 Tipo del documento: Artículo

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Texto completo: Disponible Colección: Bases de datos de organismos internacionales Base de datos: EMBASE Tipo de estudio: Estudio pronóstico Idioma: Inglés Revista: Birth Defects Research Año: 2023 Tipo del documento: Artículo