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Immunomodulatory role of Nanocurcumin in COVID-19 patients with dropped natural killer cells frequency and function.
Abbaspour-Aghdam, Sanaz; Hazrati, Ali; Abdolmohammadi-Vahid, Samaneh; Tahmasebi, Safa; Mohseni, Jafar; Valizadeh, Hamed; Nadiri, Mehdi; Mikaeili, Haleh; Sadeghi, Armin; Yousefi, Mehdi; Roshangar, Leila; Nikzad, Behzad; Jadidi-Niaragh, Farhad; Kafil, Hossein Samadi; Malekpour, Kosar; Ahmadi, Majid.
  • Abbaspour-Aghdam S; Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Hazrati A; Department of Immunology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
  • Abdolmohammadi-Vahid S; Department of Immunology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Tahmasebi S; Department of Immunology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Mohseni J; Genetics Research Group, ACECR Infertility Center, Tabriz, East Azarbaijan, Iran.
  • Valizadeh H; Tuberculosis and Lung Disease Research Center of Tabriz University of Medical Sciences, Tabriz, Iran.
  • Nadiri M; Tuberculosis and Lung Disease Research Center of Tabriz University of Medical Sciences, Tabriz, Iran.
  • Mikaeili H; Tuberculosis and Lung Disease Research Center of Tabriz University of Medical Sciences, Tabriz, Iran.
  • Sadeghi A; Tuberculosis and Lung Disease Research Center of Tabriz University of Medical Sciences, Tabriz, Iran.
  • Yousefi M; Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Roshangar L; Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Nikzad B; Research Center of Bioscience and Biotechnology, University of Tabriz, Tabriz, Iran.
  • Jadidi-Niaragh F; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Kafil HS; Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Malekpour K; Department of Immunology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
  • Ahmadi M; Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: Ahmadi.m@tbzmed.ac.ir.
Eur J Pharmacol ; 933: 175267, 2022 Oct 15.
Artículo en Inglés | MEDLINE | ID: covidwho-2031262
ABSTRACT
The ongoing COVID-19 pandemic is still a challenging problem in the case of infection treatment. The immunomodulatory effect of Nanocurcumin was investigated in the present study in an attempt to counterbalance the immune response and improve the patients' clinical symptoms. 60 confirmed COVID-19 patients and 60 healthy controls enrolled in the study. COVID-19 patients were divided into Nanocurcumin and placebo received groups. Due to the importance of the role of NK cells in this disease, the frequency, cytotoxicity, receptor gene expression of NK cells, and serum secretion levels of inflammatory cytokines IL-1ß, IL-6, TNF-α, as well as circulating C5a as a chemotactic factor an inflammatory mediator was evaluated by flow cytometry, real-time PCR and enzyme-linked immunosorbent assay in both experimental groups before and after the intervention. Given the role of measured factors in the progression and pathogenesis of COVID-19 disease, the results can help find appropriate treatments. The results of this study indicated that the Nanocurcumin could significantly increase the frequency and function of NK cells compared to the placebo-treated group. As an immunomodulatory agent, Nanocurcumin may be a helpful choice to improve NK cell function in COVID-19 patients and improve the clinical outcome of patients.
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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: Tratamiento Farmacológico de COVID-19 Tipo de estudio: Estudio experimental / Estudio observacional / Estudio pronóstico / Ensayo controlado aleatorizado Límite: Humanos Idioma: Inglés Revista: Eur J Pharmacol Año: 2022 Tipo del documento: Artículo País de afiliación: J.ejphar.2022.175267

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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: Tratamiento Farmacológico de COVID-19 Tipo de estudio: Estudio experimental / Estudio observacional / Estudio pronóstico / Ensayo controlado aleatorizado Límite: Humanos Idioma: Inglés Revista: Eur J Pharmacol Año: 2022 Tipo del documento: Artículo País de afiliación: J.ejphar.2022.175267