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The role of B cells in COVID-19 infection and vaccination.
Chen, Shiru; Guan, Fei; Candotti, Fabio; Benlagha, Kamel; Camara, Niels Olsen Saraiva; Herrada, Andres A; James, Louisa K; Lei, Jiahui; Miller, Heather; Kubo, Masato; Ning, Qin; Liu, Chaohong.
  • Chen S; Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science Technology, Wuhan, China.
  • Guan F; Department of Internal Medicine, The Division of Gastroenterology and Hepatology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Candotti F; Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science Technology, Wuhan, China.
  • Benlagha K; Division of Immunology and Allergy, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
  • Camara NOS; Institut de Recherche Saint-Louis, Université de Paris, Paris, France.
  • Herrada AA; Laboratory of Human Immunology, Department of Immunology, Institute of Biomedical Sciences, University of São Paulo (USP), São Paulo, SP, Brazil.
  • James LK; Lymphatic and Inflammation Research Laboratory, Facultad de Ciencias de la Salud, Instituto de Ciencias Biomedicas, Universidad Autonoma de Chile, Talca, Chile.
  • Lei J; Centre for Immunobiology, Bizard Institute, Queen Mary University of London, London, United Kingdom.
  • Miller H; Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science Technology, Wuhan, China.
  • Kubo M; Cytek Biosciences, R&D Clinical Reagents, Fremont, CA, United States.
  • Ning Q; Laboratory for Cytokine Regulation, Center for Integrative Medical Science (IMS), Rikagaku Kenkyusho, Institute of Physical and Chemical Research (RIKEN) Yokohama Institute, Yokohama, Kanagawa, Japan.
  • Liu C; Department of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Front Immunol ; 13: 988536, 2022.
Artículo en Inglés | MEDLINE | ID: covidwho-2039681
ABSTRACT
B cells secrete antibodies and mediate the humoral immune response, making them extremely important in protective immunity against SARS-CoV-2, which caused the coronavirus disease 2019 (COVID-19) pandemic. In this review, we summarize the positive function and pathological response of B cells in SARS-CoV-2 infection and re-infection. Then, we structure the immunity responses that B cells mediated in peripheral tissues. Furthermore, we discuss the role of B cells during vaccination including the effectiveness of antibodies and memory B cells, viral evolution mechanisms, and future vaccine development. This review might help medical workers and researchers to have a better understanding of the interaction between B cells and SARS-CoV-2 and broaden their vision for future investigations.
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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: Vacunas Virales / COVID-19 Tópicos: Vacunas Límite: Humanos Idioma: Inglés Revista: Front Immunol Año: 2022 Tipo del documento: Artículo País de afiliación: Fimmu.2022.988536

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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: Vacunas Virales / COVID-19 Tópicos: Vacunas Límite: Humanos Idioma: Inglés Revista: Front Immunol Año: 2022 Tipo del documento: Artículo País de afiliación: Fimmu.2022.988536