[Heparin-induced thrombocytopenia and vaccine-induced immune thrombotic thrombocytopenia: novel insights on anti-platelet factor 4 antibodies].
Rinsho Ketsueki
; 63(9): 1233-1241, 2022.
Artículo
en Japonés
| MEDLINE | ID: covidwho-2056364
ABSTRACT
The levels of anti-platelet factor 4 (PF4) antibodies, also known as anti-PF4 or heparin complex antibodies, are used to diagnose heparin-induced thrombocytopenia (HIT). In HIT, anti-PF4 antibodies induced by heparin exposure cause thrombocytopenia and thrombosis. However, anti-PF4 antibodies were recently reported to be associated with the development of fatal vaccine-induced immune thrombotic thrombocytopenia (VITT) after adenoviral vector vaccination for coronavirus disease 2019. HIT and VITT are caused by anti-PF4 antibodies and have similar pathological conditions. However, the severity of these conditions differs and the detection sensitivity of their antibodies varies depending on the assays used. Herein, we review HIT and VITT associated with anti-PF4 antibodies.
Palabras clave
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
Trombocitopenia
/
Trombosis
/
Factor Plaquetario 4
/
Heparina
/
Púrpura Trombocitopénica Idiopática
/
COVID-19
Tipo de estudio:
Estudios diagnósticos
/
Estudio pronóstico
Tópicos:
Covid persistente
/
Vacunas
Límite:
Humanos
Idioma:
Japonés
Revista:
Rinsho Ketsueki
Año:
2022
Tipo del documento:
Artículo
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