Host Kinase CSNK2 is a Target for Inhibition of Pathogenic SARS-like ß-Coronaviruses.
ACS Chem Biol
; 17(7): 1937-1950, 2022 07 15.
Artículo
en Inglés
| MEDLINE | ID: covidwho-2106315
ABSTRACT
Inhibition of the protein kinase CSNK2 with any of 30 specific and selective inhibitors representing different chemotypes, blocked replication of pathogenic human, bat, and murine ß-coronaviruses. The potency of in-cell CSNK2A target engagement across the set of inhibitors correlated with antiviral activity and genetic knockdown confirmed the essential role of the CSNK2 holoenzyme in ß-coronavirus replication. Spike protein endocytosis was blocked by CSNK2A inhibition, indicating that antiviral activity was due in part to a suppression of viral entry. CSNK2A inhibition may be a viable target for the development of anti-SARS-like ß-coronavirus drugs.
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
Infecciones por Coronavirus
/
Coronavirus
Límite:
Animales
/
Humanos
Idioma:
Inglés
Revista:
ACS Chem Biol
Año:
2022
Tipo del documento:
Artículo
País de afiliación:
Acschembio.2c00378
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