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Breakthrough SARS-CoV-2 Infections after Vaccination in North Carolina.
Uschner, Diane; Bott, Matthew; Lagarde, William H; Keating, Joseph; Tapp, Hazel; Berry, Andrea A; Seals, Austin L; Munawar, Iqra; Schieffelin, John; Yukich, Joshua; Santacatterina, Michele; Gunaratne, Mihili; Fette, Lida M; Burke, Brian; Strylewicz, Greg; Edelstein, Sharon L; Ahmed, Amina; Miller, Kristen; Sanders, John W; Herrington, David; Weintraub, William S; Runyon, Michael S.
  • Uschner D; The Biostatistics Center, George Washington University, Rockville, MD 20852, USA.
  • Bott M; The Biostatistics Center, George Washington University, Rockville, MD 20852, USA.
  • Lagarde WH; Division of Pediatric Endocrinology, Department of Pediatrics, WakeMed Health and Hospitals, Raleigh, NC 27610, USA.
  • Keating J; Department of Tropical Medicine, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70118, USA.
  • Tapp H; Department of Family Medicine, Atrium Health Carolinas Medical Center, Charlotte, NC 28262, USA.
  • Berry AA; Department of Pediatrics, Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
  • Seals AL; Division of Cardiology, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27109, USA.
  • Munawar I; Division of Infectious Diseases, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27109, USA.
  • Schieffelin J; Section of Infectious Disease, Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA.
  • Yukich J; Department of Tropical Medicine, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70118, USA.
  • Santacatterina M; The Biostatistics Center, George Washington University, Rockville, MD 20852, USA.
  • Gunaratne M; The Biostatistics Center, George Washington University, Rockville, MD 20852, USA.
  • Fette LM; The Biostatistics Center, George Washington University, Rockville, MD 20852, USA.
  • Burke B; The Biostatistics Center, George Washington University, Rockville, MD 20852, USA.
  • Strylewicz G; The Biostatistics Center, George Washington University, Rockville, MD 20852, USA.
  • Edelstein SL; The Biostatistics Center, George Washington University, Rockville, MD 20852, USA.
  • Ahmed A; Department of Pediatrics, Atrium Health Levine Children's Hospital, Charlotte, NC 28203, USA.
  • Miller K; MedStar Health Research Institute, Georgetown University, Washington, DC 20007, USA.
  • Sanders JW; Division of Infectious Diseases, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27109, USA.
  • Herrington D; Division of Cardiology, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27109, USA.
  • Weintraub WS; MedStar Health Research Institute, Georgetown University, Washington, DC 20007, USA.
  • Runyon MS; Department of Emergency Medicine, Atrium Health Carolinas Medical Center, Charlotte, NC 28262, USA.
Vaccines (Basel) ; 10(11)2022 Nov 13.
Artículo en Inglés | MEDLINE | ID: covidwho-2110309
ABSTRACT
We characterize the overall incidence and risk factors for breakthrough infection among fully vaccinated participants in the North Carolina COVID-19 Community Research Partnership cohort. Among 15,808 eligible participants, 638 reported a positive SARS-CoV-2 test after vaccination. Factors associated with a lower risk of breakthrough in the time-to-event analysis included older age, prior SARS-CovV-2 infection, higher rates of face mask use, and receipt of a booster vaccination. Higher rates of breakthrough were reported by participants vaccinated with BNT162b2 or Ad26.COV2.S compared to mRNA-1273, in suburban or rural counties compared to urban counties, and during circulation of the Delta and Omicron variants.
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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Tipo de estudio: Estudio de cohorte / Estudio observacional / Estudio pronóstico Tópicos: Vacunas / Variantes Idioma: Inglés Año: 2022 Tipo del documento: Artículo País de afiliación: Vaccines10111922

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Texto completo
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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Tipo de estudio: Estudio de cohorte / Estudio observacional / Estudio pronóstico Tópicos: Vacunas / Variantes Idioma: Inglés Año: 2022 Tipo del documento: Artículo País de afiliación: Vaccines10111922