Oxidative stress and viral Infections: rationale, experiences, and perspectives on N-acetylcysteine.
Eur Rev Med Pharmacol Sci
; 26(22): 8582-8590, 2022 Nov.
Artículo
en Inglés
| MEDLINE | ID: covidwho-2156090
ABSTRACT
This article explores current evidence on the role of oxidative stress in viral infections, and on the use of antioxidant drugs as adjunctive treatment. MEDLINE/PubMed was searched for appropriate keywords, and preclinical and clinical studies with reviews were retrieved and examined by authors. Old and current evidence shows that GSH content reduction is the main mechanism of redox imbalance in viral-infected cells. Clinical studies found that GSH levels are depleted in patients with viral infections such as HIV and SARS-CoV. Viral infections activate inflammation through different pathways, and several of these mechanisms are related to oxidative stress. NAC is a precursor of GSH, and many of its intracellular effects are mediated by GSH replenishment, but it also activates some anti-inflammatory mechanisms. NAC has an excellent safety profile and better oral and topical bioavailability than GSH. These characteristics make NAC a suitable option as a repurposed drug. Adjunctive antioxidant treatment may improve the outcomes of antiviral therapies. Current evidence supports the rationale for this practice and some clinical experience showed encouraging results.
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
Acetilcisteína
/
Virosis
Tipo de estudio:
Estudio pronóstico
/
Investigación cualitativa
/
Revisiones
Límite:
Humanos
Idioma:
Inglés
Revista:
Eur Rev Med Pharmacol Sci
Asunto de la revista:
Farmacología
/
Toxicología
Año:
2022
Tipo del documento:
Artículo
País de afiliación:
Eurrev_202211_30395
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