Comparing hybrid and regular COVID-19 vaccine-induced immunity against the Omicron epidemic.
NPJ Vaccines
; 7(1): 162, 2022 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: covidwho-2160220
ABSTRACT
Evidence on the effectiveness of COVID-19 vaccines among people who recovered from a previous SARS-CoV-2 infection is warranted to inform vaccination recommendations. Using the territory-wide public healthcare and vaccination records of over 2.5 million individuals in Hong Kong, we examined the potentially differential risk of SARS-CoV-2 infection, hospitalization, and mortality between those receiving two homologous doses of BNT162b2 or CoronaVac versus those with a previous infection receiving only one dose amid the Omicron epidemic. Results show a single dose after a SARS-CoV-2 infection is associated with a lower risk of infection (BNT162b2 adjusted incidence rate ratio [IRR] = 0.475, 95% CI 0.410-0.550; CoronaVac adjusted IRR = 0.397, 95% CI 0.309-0.511) and no significant difference was detected in the risk of COVID-19-related hospitalization or mortality compared with a two-dose vaccination regimen. Findings support clinical recommendations that those with a previous infection could receive a single dose to gain at least similar protection as those who received two doses without a previous infection.
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
Tópicos:
Vacunas
/
Variantes
Idioma:
Inglés
Revista:
NPJ Vaccines
Año:
2022
Tipo del documento:
Artículo
País de afiliación:
S41541-022-00594-7
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