Anti-glomerular Basement Membrane Disease Concomitant with MPO-ANCA Positivity Concurrent with High Serum Levels of Interleukin-26 Following Coronavirus Disease 2019 Vaccination.
Intern Med
; 62(7): 1043-1048, 2023 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: covidwho-2224616
ABSTRACT
As coronavirus disease 2019 (COVID-19) vaccine booster campaigns progress worldwide, new reports of complications following COVID-19 vaccination have emerged. We herein report a case of new-onset anti-glomerular basement membrane (GBM) disease concomitant with myeloperoxidase-antineutrophil cytoplasmic antibody positivity concurrent with high levels of interleukin (IL)-26 following the second dose of the Pfizer-BioNTech COVID-19 vaccine. The temporal association with vaccination in this case suggests that an enhanced neutrophilic immune response through IL-26 may have triggered necrotizing glomerulonephritis and a T-cell-mediated immune response to GBMs, leading to the development of anti-GBM antibodies, with an enhanced B-cell response after the vaccination triggering anti-GBM IgG and the onset of anti-GBM disease.
Palabras clave
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
Enfermedad por Anticuerpos Antimembrana Basal Glomerular
/
COVID-19
/
Glomerulonefritis
Tipo de estudio:
Reporte de caso
Tópicos:
Covid persistente
/
Vacunas
Límite:
Humanos
Idioma:
Inglés
Revista:
Intern Med
Asunto de la revista:
Medicina Interna
Año:
2023
Tipo del documento:
Artículo
País de afiliación:
Internalmedicine.1027-22
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