MVIP: multi-omics portal of viral infection.
Nucleic Acids Res
; 50(D1): D817-D827, 2022 01 07.
Artículo
en Inglés
| MEDLINE | ID: covidwho-2236145
ABSTRACT
Virus infections are huge threats to living organisms and cause many diseases, such as COVID-19 caused by SARS-CoV-2, which has led to millions of deaths. To develop effective strategies to control viral infection, we need to understand its molecular events in host cells. Virus related functional genomic datasets are growing rapidly, however, an integrative platform for systematically investigating host responses to viruses is missing. Here, we developed a user-friendly multi-omics portal of viral infection named as MVIP (https//mvip.whu.edu.cn/). We manually collected available high-throughput sequencing data under viral infection, and unified their detailed metadata including virus, host species, infection time, assay, and target, etc. We processed multi-layered omics data of more than 4900 viral infected samples from 77 viruses and 33 host species with standard pipelines, including RNA-seq, ChIP-seq, and CLIP-seq, etc. In addition, we integrated these genome-wide signals into customized genome browsers, and developed multiple dynamic charts to exhibit the information, such as time-course dynamic and differential gene expression profiles, alternative splicing changes and enriched GO/KEGG terms. Furthermore, we implemented several tools for efficiently mining the virus-host interactions by virus, host and genes. MVIP would help users to retrieve large-scale functional information and promote the understanding of virus-host interactions.
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
Virosis
/
Bases de Datos Factuales
/
Interacciones Microbiota-Huesped
Tipo de estudio:
Estudio pronóstico
/
Ensayo controlado aleatorizado
/
Revisiones
Límite:
Animales
/
Humanos
Idioma:
Inglés
Revista:
Nucleic Acids Res
Año:
2022
Tipo del documento:
Artículo
País de afiliación:
Nar
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