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Reduction in the number of neutrophils in the broncho-alveolar aspirate is associated with worse prognosis in elderly patients with severe COVID-19.
Arifa, Raquel Duque Nascimento; Gonçalves-Pereira, Marcela Helena; Santiago, Luciana; Ravetti, Cecilia Gómez; Vassallo, Paula Frizera; de Fátima Souza Oliveira, Fernanda; de Paula Sabino, Adriano; Teixeira, Mauro Martins; Nobre, Vandack; da Costa Santiago, Helton; Souza, Daniele G.
  • Arifa RDN; Department of Microbiology, Laboratory of Microorganism-Host Interaction, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
  • Gonçalves-Pereira MH; Department of Biochemistry and Immunology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
  • Santiago L; Department of Biochemistry and Immunology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
  • Ravetti CG; Clinical Hospital, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
  • Vassallo PF; Interdisciplinary Center for Research in Intensive Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
  • de Fátima Souza Oliveira F; Interdisciplinary Center for Research in Intensive Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
  • de Paula Sabino A; Faculty of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
  • Teixeira MM; Clinical Hospital, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
  • Nobre V; Interdisciplinary Center for Research in Intensive Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
  • da Costa Santiago H; Department of Clinical and Toxicological Analysis, College of Pharmacy, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
  • Souza DG; Department of Clinical and Toxicological Analysis, College of Pharmacy, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Inflamm Res ; 72(5): 929-932, 2023 May.
Artículo en Inglés | MEDLINE | ID: covidwho-2250176
ABSTRACT
The blood levels of neutrophils are associated with the severity of COVID -19. However, their role in the pulmonary environment during COVID -19 severity is not clear. Here, we found a decrease in the neutrophil count in BAL (bronchoalveolar lavage) in non-survivors and in older patients (> 60 years). In addition, we have shown that older patients have higher serum concentration of CXCL8 and increased IL-10 expression by neutrophils.
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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: COVID-19 / Neutrófilos Tipo de estudio: Estudio pronóstico Límite: Anciano / Humanos Idioma: Inglés Revista: Inflamm Res Asunto de la revista: Alergia e Inmunología / Patología Año: 2023 Tipo del documento: Artículo País de afiliación: S00011-023-01726-y

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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: COVID-19 / Neutrófilos Tipo de estudio: Estudio pronóstico Límite: Anciano / Humanos Idioma: Inglés Revista: Inflamm Res Asunto de la revista: Alergia e Inmunología / Patología Año: 2023 Tipo del documento: Artículo País de afiliación: S00011-023-01726-y