Low hanging fruit for combatting SARS-CoV-2?
EMBO Rep
; 24(4): e56979, 2023 04 05.
Artículo
en Inglés
| MEDLINE | ID: covidwho-2253688
ABSTRACT
Entry of SARS-CoV-2 into human respiratory cells, mediated by the spike protein, is absolutely dependent on the cellular receptor ACE2 (angiotensin-converting enzyme-2). This makes ACE2 an attractive target for therapeutic intervention in COVID-19. In this issue, Zuo et al. discover that vitamin C, an essential nutrient and common dietary supplement, can target ACE2 for ubiquitin-dependent degradation, resulting in the inhibition of SARS-CoV-2 infection (Zuo et al, 2023). The study identifies novel mechanisms of cellular ACE2 regulation and may inform the design of therapeutics targeting SARS-2 and related coronaviruses.
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
SARS-CoV-2
/
COVID-19
Tópicos:
Medicina tradicional
Límite:
Humanos
Idioma:
Inglés
Revista:
EMBO Rep
Asunto de la revista:
Biologia Molecular
Año:
2023
Tipo del documento:
Artículo
País de afiliación:
Embr.202356979
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