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COVID-19 mRNA Vaccine Effectiveness against Elderly Frail People.
Kountouras, Jannis; Tzitiridou-Chatzopoulou, Maria; Papaefthymiou, Apostolis; Chatzopoulos, Dimitrios; Doulberis, Michael.
  • Kountouras J; Second Medical Clinic, School of Medicine, Ippokration Hospital, Aristotle University of Thessaloniki, 54642 Thessaloniki, Greece.
  • Tzitiridou-Chatzopoulou M; Second Medical Clinic, School of Medicine, Ippokration Hospital, Aristotle University of Thessaloniki, 54642 Thessaloniki, Greece.
  • Papaefthymiou A; Midwifery Department, School of Healthcare Sciences, University of West Macedonia, Koila, 50100 Kozani, Greece.
  • Chatzopoulos D; Second Medical Clinic, School of Medicine, Ippokration Hospital, Aristotle University of Thessaloniki, 54642 Thessaloniki, Greece.
  • Doulberis M; Department of Gastroenterology, University Hospital of Larisa, 41110 Larisa, Greece.
Medicina (Kaunas) ; 59(2)2023 Jan 19.
Artículo en Inglés | MEDLINE | ID: covidwho-2267108
ABSTRACT
The frail, elderly population is often characterized by poor immunogenicity post COVID-19 mRNA vaccination. "Inflame-ageing" and "immune-senescence" are pathogenetic mechanisms that might explain this phenomenon. Complex interplay with cytokines and microbiota is also implicated in this inflammatory cascade. The abovementioned population, although very important from immunologic perspective, has barely been included in the mRNA vaccination clinical trials.
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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: Anciano Frágil / COVID-19 Tipo de estudio: Estudio experimental / Estudio pronóstico Tópicos: Covid persistente / Vacunas Límite: Anciano / Humanos Idioma: Inglés Asunto de la revista: Medicina Año: 2023 Tipo del documento: Artículo País de afiliación: Medicina59020202

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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: Anciano Frágil / COVID-19 Tipo de estudio: Estudio experimental / Estudio pronóstico Tópicos: Covid persistente / Vacunas Límite: Anciano / Humanos Idioma: Inglés Asunto de la revista: Medicina Año: 2023 Tipo del documento: Artículo País de afiliación: Medicina59020202