Relationship of fibrinolysis system proteins with severity of COVID-19. A review of current clinical data and promising therapeutic strategies

ABSTRACT

Modern clinical studies show the association of fibrinolysis system factors with complications following COVID-19. This review includes the studies describing the relationship of urokinase plasminogen activator proteins uPA and its receptor uPAR, plasmin-ogen activator inhibitor PAI-1 and plasmin itself with severity of COVID-19. Potential of diagnosis based on analysis of concen-trations and activities of these proteins, as well as expression of their encoding genes is described. These data can predict severe course and possible complications of COVID-19 including thrombosis, respiratory failure and cytokine storm. © 2022, Media Sphera Publishing Group. All rights reserved.