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A quantitative model for human neurovascular coupling with translated mechanisms from animals.
Sten, Sebastian; Podéus, Henrik; Sundqvist, Nicolas; Elinder, Fredrik; Engström, Maria; Cedersund, Gunnar.
  • Sten S; Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.
  • Podéus H; Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden.
  • Sundqvist N; Department of Biomedical Engineering, Linköping University, Linköping, Sweden.
  • Elinder F; Department of Biomedical Engineering, Linköping University, Linköping, Sweden.
  • Engström M; Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden.
  • Cedersund G; Department of Biomedical Engineering, Linköping University, Linköping, Sweden.
PLoS Comput Biol ; 19(1): e1010818, 2023 01.
Artículo en Inglés | MEDLINE | ID: covidwho-2280349
ABSTRACT
Neurons regulate the activity of blood vessels through the neurovascular coupling (NVC). A detailed understanding of the NVC is critical for understanding data from functional imaging techniques of the brain. Many aspects of the NVC have been studied both experimentally and using mathematical models; various combinations of blood volume and flow, local field potential (LFP), hemoglobin level, blood oxygenation level-dependent response (BOLD), and optogenetics have been measured and modeled in rodents, primates, or humans. However, these data have not been brought together into a unified quantitative model. We now present a mathematical model that describes all such data types and that preserves mechanistic behaviors between experiments. For instance, from modeling of optogenetics and microscopy data in mice, we learn cell-specific contributions; the first rapid dilation in the vascular response is caused by NO-interneurons, the main part of the dilation during longer stimuli is caused by pyramidal neurons, and the post-peak undershoot is caused by NPY-interneurons. These insights are translated and preserved in all subsequent analyses, together with other insights regarding hemoglobin dynamics and the LFP/BOLD-interplay, obtained from other experiments on rodents and primates. The model can predict independent validation-data not used for training. By bringing together data with complementary information from different species, we both understand each dataset better, and have a basis for a new type of integrative analysis of human data.
Asunto(s)

Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: Acoplamiento Neurovascular Tipo de estudio: Estudio pronóstico Límite: Animales / Humanos Idioma: Inglés Revista: PLoS Comput Biol Asunto de la revista: Biologia / Informática Médica Año: 2023 Tipo del documento: Artículo País de afiliación: Journal.pcbi.1010818

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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: Acoplamiento Neurovascular Tipo de estudio: Estudio pronóstico Límite: Animales / Humanos Idioma: Inglés Revista: PLoS Comput Biol Asunto de la revista: Biologia / Informática Médica Año: 2023 Tipo del documento: Artículo País de afiliación: Journal.pcbi.1010818