Adipocytes Encapsulating Telratolimod Recruit and Polarize Tumor-Associated Macrophages for Cancer Immunotherapy.
Adv Sci (Weinh)
; 10(5): e2206001, 2023 02.
Artículo
en Inglés
| MEDLINE | ID: covidwho-2286536
ABSTRACT
Tumor-associated adipocytes (TAAs) recruit monocytes and promote their differentiation into tumor-associated macrophages (TAMs) that support tumor development. Here, TAAs are engineered to promote the polarization of TAMs to the tumor suppressive M1 phenotype. Telratolimod, a toll-like receptor 7/8 agonist, is loaded into the lipid droplets of adipocytes to be released at the tumor site upon tumor cell-triggered lipolysis. Locally administered drug-loaded adipocytes increased tumor suppressive M1 macrophages in both primary and distant tumors and suppressed tumor growth in a melanoma model. Furthermore, drug-loaded adipocytes improved CD8+ T cell-mediated immune responses within the tumor microenvironment and favored dendritic cell maturation in the tumor draining lymph nodes.
Palabras clave
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
Macrófagos Asociados a Tumores
/
Melanoma
Tipo de estudio:
Risk_factors_studies
Límite:
Humanos
Idioma:
Inglés
Revista:
Adv Sci (Weinh)
Año:
2023
Tipo del documento:
Artículo
País de afiliación:
Advs.202206001
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