Diagnostic value of blood oxygen saturation and C-Reactive Protein (CRP) in Predicting Lung Sequels in COVID-19 infected patients admitted to hospital: A 12-week cohort study
Galen Medical Journal
; 12 (no pagination), 2023.
Artículo
en Inglés
| EMBASE | ID: covidwho-2290528
ABSTRACT
Background:
Evidence of COVID-19 respiratory sequels is restricted and predisposing factors are not well studied more than two years passing pandemic. This study followed COVID-19 patients 12 weeks after discharge from hospital for respiratory sequels. Material(s) and Method(s) This was a prospective study on discharged COVID-19 patients in 2021, in Jahrom, Iran. Exposure was COVID-19 clinical features at hospitalization, including symptoms and physical examination and laboratory findings, and primary endpoint was 12-week lung sequel, being evaluated by a chest CT scan. Demographics and previous medical history were considered covariates. SPO2and CRP 6-week changes were followed as an early tool for prediction of 12-week lung sequel. Result(s) Totally, 383 participants (17 had sequels) with mean age of 57.43 18.03 years old (50.13% male) completed 12-week study follow-ups. Ninety-one (23.8%) subjects had an ICU admission history. SPO2% in 6th week was statistically significantly associated with a higher rate of 12-week sequelae (p<0.001). Also, patients having CT scan scores between 40% to 50% (p=0.012) and higher than 50% (p=0.040) had higher chance of experiencing lung sequelae than patients with CT scan score of below 40%, as well as having ICU admission history and lower SPO2% at 6th week of discharge. There was a statistically significant increasing trend of SPO2% (P<0.001) and a statistically significant decreasing trend of CRP levels (P<0.001), overall. SPO2% increase after 6 weeks was lower in participants with lung sequels than fully improved ones (P=0.002) and as well as total 12-week change in SPO2% (P=0.001). CRP changes in none of evaluated periods were different among study groups (P>0.05). Conclusion(s) Our results were in favor of closely following SPO2levels after patient discharge, while CRP assessment seems not helpful based on our results [GMJ.2023;12e2695].Copyright © 2023 Shiraz University of Medical Sciences. All rights reserved.
covid-19; Lung; Oxygen; Respiratory; adult; article; chronic obstructive lung disease/di [Diagnosis]; chronic obstructive lung disease/ep [Epidemiology]; clinical feature; cohort analysis; computer assisted tomography; coronavirus disease 2019; coughing; diabetes mellitus; diagnostic test accuracy study; diagnostic value; dyspnea; echocardiography; female; fever; heart disease; high resolution computer tomography; hospital admission; hospital discharge; hospitalization; human; intensive care unit; male; outcome assessment; oxygen blood level; oxygen saturation; pandemic; physical examination; polymerase chain reaction; prediction; prevalence; prospective study; pulse oximetry; respiratory distress; thorax radiography; C reactive protein/ec [Endogenous Compound]; pulse oximeter; lung sequalae/di [Diagnosis]; lung sequalae/ep [Epidemiology]
Texto completo:
Disponible
Colección:
Bases de datos de organismos internacionales
Base de datos:
EMBASE
Tipo de estudio:
Estudio de cohorte
/
Estudio observacional
/
Estudio pronóstico
Idioma:
Inglés
Revista:
Galen Medical Journal
Año:
2023
Tipo del documento:
Artículo
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