Multisystem inflammatory syndrome in children: A dysregulated autoimmune disorder following COVID-19.
J Microbiol Immunol Infect
; 56(2): 236-245, 2023 Apr.
Artículo
en Inglés
| MEDLINE | ID: covidwho-2298597
ABSTRACT
Multisystem inflammatory syndrome in children (MIS-C) is a dysregulated autoimmune-mediated illness in genetically susceptible patients following COVID-19 with an interval of 2-6 weeks. The median age of patients with MIS-C is 6-11 years. Most common manifestations are involvement of gastrointestinal tract, cardiovascular system, hematological system, and mucocutaneous system. Respiratory tract, neurological system, musculoskeletal system, and kidney are less frequently affected. Mucocutaneous manifestations and coronary artery abnormalities characteristic for Kawasaki disease (KD) may be observed in a significant proportion of MIS-C patients that may make the differential diagnosis be difficult for some patients, especially in the post-pandemic era. The mortality rate is 1-3%. Management and prognosis of MIS-C are similar to that of KD. MIS-C and KD may share a common pathogenic process. Based on the observation of MIS-C-like illness in uninfected neonates, i.e. multisystem inflammatory syndrome in neonates, both MIS-C and KD may be a consequence of dysregulated, over-exaggerated humoral immune responses triggered by a specific infectious agent.
Palabras clave
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
Enfermedades Autoinmunes
/
COVID-19
/
Síndrome Mucocutáneo Linfonodular
Tipo de estudio:
Estudios diagnósticos
/
Estudio observacional
/
Estudio pronóstico
Tópicos:
Covid persistente
Límite:
Niño
/
Humanos
/
Recién Nacido
Idioma:
Inglés
Revista:
J Microbiol Immunol Infect
Asunto de la revista:
Alergia e Inmunología
/
Microbiologia
Año:
2023
Tipo del documento:
Artículo
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