Safety of COVID-19 vaccines in multiple sclerosis: A systematic review and meta-analysis.
Mult Scler
; 29(4-5): 585-594, 2023 04.
Artículo
en Inglés
| MEDLINE | ID: covidwho-2299594
ABSTRACT
BACKGROUND:
Data are sparse regarding the safety of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines in patients with multiple sclerosis (MS).OBJECTIVE:
To estimate (1) the pooled proportion of MS patients experiencing relapse among vaccine recipients; (2) the rate of transient neurological worsening, adverse events, and serious adverse events; (3) the previous outcomes of interest for different SARS-CoV-2 vaccine types.METHODS:
Systematic review and meta-analysis of pharmacovigilance registries and observational studies.RESULTS:
Nineteen observational studies comprising 14,755 MS patients who received 23,088 doses of COVID-19 vaccines were included. Mean age was 43.3 years (95% confidence interval (CI) 40-46.6); relapsing-remitting, secondary-progressive, primary-progressive MS and clinically isolated syndrome were diagnosed in 82.6% (95% CI 73.9-89.8), 12.6% (95% CI 6.3-20.8), 6.7% (95% CI 4.2-9.9), and 2.9% (95% CI 1-5.9) of cases, respectively. The pooled proportion of MS patients experiencing relapse at a mean time interval of 20 days (95% CI 12-28.2) from vaccination was 1.9% (95% CI 1.3%-2.6%; I2 = 78%), with the relapse risk being independent of the type of administered SARS-CoV-2-vaccine (p for subgroup differences = 0.7 for messenger RNA (mRNA), inactivated virus, and adenovector-based vaccines). After vaccination, transient neurological worsening was observed in 4.8% (95% CI 2.3%-8.1%) of patients. Adverse events and serious adverse events were reported in 52.8% (95% CI 46.7%-58.8%) and 0.1% (95% CI 0%-0.2%) of vaccinations, respectively.CONCLUSION:
COVID-19 vaccination does not appear to increase the risk of relapse and serious adverse events in MS. Weighted against the risks of SARS-CoV-2-related complications and MS exacerbations, these safety data provide compelling pro-vaccination arguments for MS patients.Palabras clave
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
COVID-19
/
Esclerosis Múltiple
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
/
Revisiones
/
Revisión sistemática/Meta análisis
Tópicos:
Covid persistente
/
Vacunas
Límite:
Adulto
/
Humanos
Idioma:
Inglés
Revista:
Mult Scler
Asunto de la revista:
Neurología
Año:
2023
Tipo del documento:
Artículo
País de afiliación:
13524585221150881
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