The effect of COVID-19 on vascular elasticity and liver function in overweight patients.
Profilakticheskaya Meditsina
; 26(2):69-78, 2023.
Artículo
en Ruso
| EMBASE | ID: covidwho-2300808
ABSTRACT
Objective. To study the changes in the vascular wall, vascular age and metabolic parameters in polymorbid COVID-19 conva-lescents. Material and methods. The study included 62 patients with hypertension who reached the target blood pressure (BP) with dual an-tihypertensive therapy after severe and extremely severe COVID-19. The following examinations were performed laboratory tests of metabolic parameters, assessment of changes in the vessel elasticity indices (pulse-wave velocity (PWV), augmentation index (AI), central systolic BP (cSBP), 24-hour BP monitoring, and non-invasive markers of liver fibrosis. Results. According to office BP measurements, after the coronavirus infection, an increase in systolic BP (SBP) by 29.6% and di-astolic BP (DBP) by 23.6%, as well as heart rate (HR) by 11.8% (p<0.05) was reported during regular antihypertensive therapy. In addition, 24-hour BP monitoring data indicated an increase in the average daily SBP, DBP, and heart rate. After the coronavirus infection, an increase in PWV by 35.4% (p<0.05), AI by 24.4% (p<0.05), cSBP by 22.1% were reported. Carbohydrate and lipid metabolism parameters deteriorated. A pronounced adverse effect of coronavirus infection on liver function was observed. The vascular age (according to the modified SCORE scale) increased by 6 years (p<0.05). Conclusion. Our study showed that patients after severe and extremely severe COVID-19 have a high risk of liver fibrosis, hypertension and lipid metabolism control worsening and accelerating vascular aging.Copyright © 2023, Media Sphera Publishing Group. All rights reserved.
covid-19; hypertension; liver fibrosis; metabolic syndrome; novel coronavirus infection; vascular aging; vascular elasticity; adverse outcome; antihypertensive therapy; article; augmentation index; biological age; blood pressure; blood pressure monitoring; blood vessel function; blood vessel parameters; carbohydrate metabolism; cardiovascular disease assessment; coronavirus disease 2019; diastolic blood pressure; disease severity; elasticity; heart rate; human; hypertension/dt [Drug Therapy]; hypertensive patient; laboratory test; lipid metabolism; liver function; major clinical study; metabolic parameters; non invasive measurement; obese patient; obesity; pulse wave velocity; systolic blood pressure; antihypertensive agent/dt [Drug Therapy]; modified SCORE scale; vascular age
Texto completo:
Disponible
Colección:
Bases de datos de organismos internacionales
Base de datos:
EMBASE
Tipo de estudio:
Estudio experimental
Idioma:
Ruso
Revista:
Profilakticheskaya Meditsina
Año:
2023
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS