Hospital Clonal Outbreak of Fluconazole-Resistant Candida parapsilosis Harboring the Y132F ERG11p Substitution in a French Intensive Care Unit.

Presente, Simona; Bonnal, Christine; Normand, Anne-Cécile; Gaudonnet, Yannick; Fekkar, Arnaud; Timsit, Jean-François; Kernéis, Solen

Presente, Simona; Bonnal, Christine; Normand, Anne-Cécile; Gaudonnet, Yannick; Fekkar, Arnaud; Timsit, Jean-François; Kernéis, Solen.

Presente S; Medical and infectious diseases ICU, APHP, Bichat hospital, Paris, France.
Bonnal C; Laboratoire de parasitologie mycologie, AP-HP, Hôpital Bichat Claude Bernard, Paris, France.
Normand AC; Laboratoire de parasitologie mycologie, AP-HP, Hôpital Pitié Salpêtrière, Paris, France.
Gaudonnet Y; Equipe de Prévention du Risque Infectieux, AP-HP, Hôpital Bichat, Paris, France.
Fekkar A; Laboratoire de parasitologie mycologie, AP-HP, Hôpital Pitié Salpêtrière, Paris, France.
Timsit JF; Medical and infectious diseases ICU, APHP, Bichat hospital, Paris, France.
Kernéis S; Université Paris Cité, INSERM, IAME, Paris, France.

Antimicrob Agents Chemother ; 67(3): e0113022, 2023 03 16.

Artículo en Inglés | MEDLINE | ID: covidwho-2302042

ABSTRACT

ABSTRACT

We report the first identification of a fluconazole-resistant Candida parapsilosis (FR-Cp) strain in our hospital, which subsequently caused an outbreak involving 17 patients (12 deaths) within a 26-bed French intensive care unit. Microsatellite genotyping confirmed that all FR-Cp isolates belonged to the same clone. Given recent reports of rapid dissemination of these emerging clones, routine testing of azole susceptibility for all Candida parapsilosis isolates should be encouraged, at least in ICU patients.

Asunto(s)

Candida parapsilosis; Fluconazol; Humanos; Fluconazol/farmacología; Fluconazol/uso terapéutico; Candida parapsilosis/genética; Antifúngicos/farmacología; Antifúngicos/uso terapéutico; Farmacorresistencia Fúngica/genética; Pruebas de Sensibilidad Microbiana; Unidades de Cuidados Intensivos; Brotes de Enfermedades; Hospitales

Palabras clave

Candida parapsilosis; fluconazole resistance; infection prevention and control; intensive care unit; outbreak

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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: Fluconazol / Candida parapsilosis Límite: Humanos Idioma: Inglés Revista: Antimicrob Agents Chemother Año: 2023 Tipo del documento: Artículo País de afiliación: Aac.01130-22

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