Engineering Extracellular Vesicles as Delivery Systems in Therapeutic Applications.
Adv Sci (Weinh)
; 10(17): e2300552, 2023 06.
Artículo
en Inglés
| MEDLINE | ID: covidwho-2305488
ABSTRACT
Extracellular vesicles (EVs) are transport vesicles secreted by living cells and released into the extracellular environment. Recent studies have shown that EVs serve as "messengers" in intercellular and inter-organismal communication, in both normal and pathological processes. EVs, as natural nanocarriers, can deliver bioactivators in therapy with their endogenous transport properties. This review article describes the engineering EVs of sources, isolation method, cargo loading, boosting approach, and adjustable targeting of EVs. Furthermore, the review summarizes the recent progress made in EV-based delivery systems applications, including cancer, cardiovascular diseases, liver, kidney, nervous system diseases, and COVID-19 and emphasizes the obstacles and challenges of EV-based therapies and possible strategies.
Palabras clave
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
Vesículas Extracelulares
/
COVID-19
/
Neoplasias
Límite:
Humanos
Idioma:
Inglés
Revista:
Adv Sci (Weinh)
Año:
2023
Tipo del documento:
Artículo
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