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COVID-19 infection in patients with haematological malignancies: A single-centre survey in the latest Omicron wave in China.
Zhu, Xiaolu; Jiang, Qian; Lu, Jin; Sun, Yuqian; Zhao, Xiaosu; Yang, Shenmiao; Tang, Feifei; Yu, Wenjing; Zhao, Ting; Liu, Xiaohong; Jia, Jinsong; Duan, Wenbing; Hu, Lijuan; Wang, Jing; Liu, Yang; Peng, Nan; Dou, Xuelin; Ma, Rui; Fu, Qiang; Wang, Huifang; Liu, Kaiyan; Huang, Xiaojun; Jiang, Hao.
  • Zhu X; National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Peking University People's Hospital, Peking University Institute of Hematology, Peking University, Beijing, China.
  • Jiang Q; National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Peking University People's Hospital, Peking University Institute of Hematology, Peking University, Beijing, China.
  • Lu J; National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Peking University People's Hospital, Peking University Institute of Hematology, Peking University, Beijing, China.
  • Sun Y; National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Peking University People's Hospital, Peking University Institute of Hematology, Peking University, Beijing, China.
  • Zhao X; National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Peking University People's Hospital, Peking University Institute of Hematology, Peking University, Beijing, China.
  • Yang S; National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Peking University People's Hospital, Peking University Institute of Hematology, Peking University, Beijing, China.
  • Tang F; National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Peking University People's Hospital, Peking University Institute of Hematology, Peking University, Beijing, China.
  • Yu W; National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Peking University People's Hospital, Peking University Institute of Hematology, Peking University, Beijing, China.
  • Zhao T; National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Peking University People's Hospital, Peking University Institute of Hematology, Peking University, Beijing, China.
  • Liu X; National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Peking University People's Hospital, Peking University Institute of Hematology, Peking University, Beijing, China.
  • Jia J; National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Peking University People's Hospital, Peking University Institute of Hematology, Peking University, Beijing, China.
  • Duan W; National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Peking University People's Hospital, Peking University Institute of Hematology, Peking University, Beijing, China.
  • Hu L; National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Peking University People's Hospital, Peking University Institute of Hematology, Peking University, Beijing, China.
  • Wang J; National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Peking University People's Hospital, Peking University Institute of Hematology, Peking University, Beijing, China.
  • Liu Y; National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Peking University People's Hospital, Peking University Institute of Hematology, Peking University, Beijing, China.
  • Peng N; National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Peking University People's Hospital, Peking University Institute of Hematology, Peking University, Beijing, China.
  • Dou X; National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Peking University People's Hospital, Peking University Institute of Hematology, Peking University, Beijing, China.
  • Ma R; National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Peking University People's Hospital, Peking University Institute of Hematology, Peking University, Beijing, China.
  • Fu Q; National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Peking University People's Hospital, Peking University Institute of Hematology, Peking University, Beijing, China.
  • Wang H; National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Peking University People's Hospital, Peking University Institute of Hematology, Peking University, Beijing, China.
  • Liu K; National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Peking University People's Hospital, Peking University Institute of Hematology, Peking University, Beijing, China.
  • Huang X; National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Peking University People's Hospital, Peking University Institute of Hematology, Peking University, Beijing, China.
  • Jiang H; Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.
Br J Haematol ; 202(1): 31-39, 2023 07.
Artículo en Inglés | MEDLINE | ID: covidwho-2306618
ABSTRACT
As the COVID-19 variant Omicron surge in Beijing, China, a better understanding of risk factors for adverse outcomes may improve clinical management in patients with haematological malignancies (HM) diagnosed with COVID-19. The study sample includes 412 cases, mainly represented by acute leukaemia, chronic myeloid leukaemia (CML), plasma cell disorders and lymphoma and chronic lymphocytic leukaemia. COVID-19 pneumonia was observed in 10.4% (43/412) of patients, and severe/critical illness was observed in 5.3% (22/412). Among the 86 cases with advanced malignancies, 17.6% (12/86) of patients developed severe/critical COVID-19, which was significantly higher than reported in patients with stable malignancies (9/326, 2.70%, p < 0.001). Similarly, the advanced malignancy cohort had a higher mortality rate (9/86, 10.5% vs. 0/326, 0%, p < 0.001) and a poor 30-day overall survival (OS) compared with the stable malignancy cohort (74.2% vs. 100.0%, p < 0.0001). Overall, nine patients (2.2%) died. The primary cause of death was progressive HM in four patients and a combination of both COVID-19 and HM in five patients. In the multivariable analysis, over 65 years of age, comorbidities and advanced malignancy were correlated with severe/critical COVID-19 in HM patients. This study sheds light on the poor outcomes among COVID-19 HM patients with the leading cause of advanced malignancy.
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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: Leucemia Linfocítica Crónica de Células B / Neoplasias Hematológicas / COVID-19 Tipo de estudio: Estudio de cohorte / Estudio observacional / Estudio pronóstico Tópicos: Variantes Límite: Humanos Idioma: Inglés Revista: Br J Haematol Año: 2023 Tipo del documento: Artículo País de afiliación: Bjh.18823

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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: Leucemia Linfocítica Crónica de Células B / Neoplasias Hematológicas / COVID-19 Tipo de estudio: Estudio de cohorte / Estudio observacional / Estudio pronóstico Tópicos: Variantes Límite: Humanos Idioma: Inglés Revista: Br J Haematol Año: 2023 Tipo del documento: Artículo País de afiliación: Bjh.18823