Influence of a multiple polymerase chain reaction panel on the diagnosis or discard of ventilator-associated pneumonia in a Chilean COVID-19 critical patients cohort
Revista Chilena De Infectologia
; 39(4):388-397, 2022.
Artículo
en Inglés
| Web of Science | ID: covidwho-2307445
ABSTRACT
Background:
Ventilator-associated pneumonia (VAP) is frequent in critical COVID-19 patients. Its early diagnosis is essential for its prognosis.Aim:
To demonstrate the usefulness of the FilmArray Pneumo panel (FAP-P) in confirming or ruling out VAP in these patients.Methods:
Retrospective study of 71 critical COVID-19 patients with suspected VAP in whom cultures and FAP-P were performed for diagnostic confirmation. Clinical characteristics, microbiology and mortality are described. The validity and safety of FAP-P is defined.Results:
The use of FAP-P and cultures ruled out VAP in 29 patients (40.8%). In 41 patients, VAP was confirmed and the 30-day mortality was 48.8%. Forty-eight samples were studied, the cultures were positive in 30 (62.5%) and 33 bacteria were detected, FAP-P detected 32 of these 33 bacteria;37 bacteria were exclusively detected by PFA-P. The most prevalent bacteria were Klebsiella pneumoniae (31.4%), Pseudomonas aeruginosa (21.4%) and Acinetobacter calcoaceticus-baumannii (14.2%). The sensitivity, specificity, positive predictive value and negative predictive value of FAP-P with respect to cultures were 96.9%, 92.5%, 46.4% and 99.8%, respectively. One patient had VAP due to Burkholderia cepacia bacteria not detected by FAP-P.Conclusions:
FAP-P is an effective molecular technique to rule out and diagnose VAP, allowing rapid suspension of antibiotics or early targeted treatment.
Buscar en Google
Colección:
Bases de datos de organismos internacionales
Base de datos:
Web of Science
Tipo de estudio:
Estudio de cohorte
/
Estudio observacional
/
Estudio pronóstico
País/Región como asunto:
America del Sur
/
Chile
Idioma:
Inglés
Revista:
Revista Chilena De Infectologia
Año:
2022
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS