NAD+ metabolism-based immunoregulation and therapeutic potential.
Cell Biosci
; 13(1): 81, 2023 May 10.
Artículo
en Inglés
| MEDLINE | ID: covidwho-2314426
ABSTRACT
Nicotinamide adenine dinucleotide (NAD+) is a critical metabolite that acts as a cofactor in energy metabolism, and serves as a cosubstrate for non-redox NAD+-dependent enzymes, including sirtuins, CD38 and poly(ADP-ribose) polymerases. NAD+ metabolism can regulate functionality attributes of innate and adaptive immune cells and contribute to inflammatory responses. Thus, the manipulation of NAD+ bioavailability can reshape the courses of immunological diseases. Here, we review the basics of NAD+ biochemistry and its roles in the immune response, and discuss current challenges and the future translational potential of NAD+ research in the development of therapeutics for inflammatory diseases, such as COVID-19.
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Idioma:
Inglés
Revista:
Cell Biosci
Año:
2023
Tipo del documento:
Artículo
País de afiliación:
S13578-023-01031-5
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