Immune responses related to the immunogenicity and reactogenicity of COVID-19 mRNA vaccines.
Int Immunol
; 35(5): 213-220, 2023 05 08.
Artículo
en Inglés
| MEDLINE | ID: covidwho-2317051
ABSTRACT
Vaccination for the prevention of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection is considered the most promising approach to control the pandemic of coronavirus disease 2019 (COVID-19). Although various COVID-19 vaccines have been developed worldwide using several modalities, the vaccines that have shown the highest efficacy to date are mRNA vaccines. Despite their extensive usage, the mechanisms that stimulate the immune responses associated with their immunogenicity and reactogenicity remain largely unknown. In this review, we summarize and discuss current knowledge on immune responses to COVID-19 mRNA vaccines, including potential immune responses and correlating factors underlying the immunogenicity and reactogenicity of mRNA vaccines. We also describe recent trends in the optimization of lipid nanoparticles and vaccination routes. Further understanding of vaccine-elicited immune responses will guide the development of more effective and safe vaccines.
Palabras clave
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
Vacunas contra la COVID-19
/
COVID-19
Tópicos:
Vacunas
Límite:
Humanos
Idioma:
Inglés
Revista:
Int Immunol
Asunto de la revista:
Alergia e Inmunología
Año:
2023
Tipo del documento:
Artículo
País de afiliación:
Intimm
Similares
MEDLINE
...
LILACS
LIS